897932-88-6

Basic information

• Product Name: 3-cyano-3,3-diphenylpropylpiperazine-1-carbodithioate
• Synonyms: 3-cyano-3,3-diphenylpropylpiperazine-1-carbodithioate
• CAS NO: 897932-88-6
• Molecular Weight: 381.566
• Mol File: 897932-88-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-cyano-3,3-diphenylpropylpiperazine-1-carbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyano-3,3-diphenylpropylpiperazine-1-carbodithioate(897932-88-6)
• EPA Substance Registry System: 3-cyano-3,3-diphenylpropylpiperazine-1-carbodithioate(897932-88-6)

Safety Data

• Hazardous Substances Data: 897932-88-6(Hazardous Substances Data)

Upstream product

• 86-29-3 Diphenylacetonitrile 
• 110-85-0 piperazine 
• 75-15-0 carbon disulfide 
• 39186-58-8 4-bromo-2,2-diphenylbutyronitrile 

Downstream Products

• 1227458-10-7 (S)-3-cyano-3,3-diphenylpropyl 4-(3-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propyl)piperazine-1-carbodithioate 
• 1227458-38-9 (S)-3-cyano-3,3-diphenylpropyl 4-(3-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)propyl)piperazine-1-carbodithioate 
• 1227458-12-9 (S)-3-cyano-3,3-diphenylpropyl 4-(5-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl)piperazine-1-carbodithioate 
• 1227458-42-5 (S)-3-cyano-3,3-diphenylpropyl 4-(5-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)pentyl)piperazine-1-carbodithioate 
• 1227458-11-8 (S)-3-cyano-3,3-diphenylpropyl 4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)butyl)piperazine-1-carbodithioate 
• 1227458-40-3 (S)-3-cyano-3,3-diphenylpropyl 4-(4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl)piperazine-1-carbodithioate 
• 1227458-37-8 (S)-3-cyano-3,3-diphenylpropyl 4-(3-(4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy)propyl)piperazine-1-carbodithioate 
• 1227458-41-4 (S)-3-cyano-3,3-diphenylpropyl 4-(5-(4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy)pentyl)piperazine-1-carbodithioate 
• 1227458-39-0 (S)-3-cyano-3,3-diphenylpropyl 4-(4-(4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy)butyl)piperazine-1-carbodithioate 

Relevant articles and documents

Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: Synthesis, DNA-binding affinity and cytotoxic activity

A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo[2,1-c][1,4]benzodiazepine conjugates (5a-c, 6a,b) have been synthesized and evaluated for their cytotoxic potential and DNA-binding ability. The representative conjugates 5a and 5b have

Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters

A variety of 4-N atom substituted derivatives were synthesized and evaluated for their in vitro anticancer activities using 4-methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester 4 as lead compound. Among them, compound 6a without any substituent on 4-N atom (R1 = H) was found to be the most active anticancer agent with IC50 = 5.3 μM against HL-60 and IC50 = 11.5 μM against Bel-7402, respectively. Increase in the polarity and/or introduction of suitable acyl groups at the 4-N atom of the lead compound 4 are favorable for the improvement of activity.