89795-51-7

Basic information

• Product Name: 2,1,3-Benzothiadiazol-5-ylmethanol
• Synonyms: 2,1,3-BENZOTHIADIAZOL-5-YLMETHANOL;1,2,3-BENZOTHIADIAZOL-5-YLMETHANOL;RARECHEM AL BD 1094;2,1,3-Benzothiadiazole-5-methanol;benzo[c][1,2,5]thiadiazol-5-ylMethanol
• CAS NO: 89795-51-7
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.2
• Mol File: 89795-51-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 61-63
• Boiling Point: 313.5 °C at 760 mmHg
• Flash Point: 143.4 °C
• Appearance: /
• Density: 1.466 g/cm³
• Vapor Pressure: 0.000211mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,1,3-Benzothiadiazol-5-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1,3-Benzothiadiazol-5-ylmethanol(89795-51-7)
• EPA Substance Registry System: 2,1,3-Benzothiadiazol-5-ylmethanol(89795-51-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 89795-51-7(Hazardous Substances Data)

Usage

General Description

2,1,3-Benzothiadiazol-5-ylmethanol is a chemical compound with the molecular formula C8H7NOS. It belongs to the class of benzothiadiazole derivatives and is commonly used in the field of organic chemistry and material science. 2,1,3-Benzothiadiazol-5-ylmethanol is known for its electron-accepting properties, making it suitable for use in organic semiconductors and optoelectronic devices. It has been studied for its potential applications in the development of organic photovoltaics, light-emitting diodes, and organic field-effect transistors. Additionally, 2,1,3-Benzothiadiazol-5-ylmethanol has been investigated for its biological properties and potential medicinal applications. Its unique structure and properties make it a versatile compound with various potential uses in different fields of science and technology.

InChI:InChI=1/C7H6N2OS/c10-4-5-1-2-6-7(3-5)9-11-8-6/h1-3,10H,4H2

Upstream product

• 304-59-6 Rochelle's salt 
• 175204-21-4 methyl benzo-2,1,3-thiadiazole-5-carboxylate 
• 71605-72-6 benzo[c][1,2,5]thiadiazole-5-carbaldehyde 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 619-05-6 3,4-diaminobenzoic acid 
• 16405-98-4 benzo[c][1,2,5]thiadiazole-5-carboxylic acid 
• 1457-93-8 5-methylbenzo[c][1,2,5]thiadiazole 
• 65858-50-6 5-bromomethyl-benzo[1,2,5]thiadiazole 

Downstream Products

• 71605-72-6 benzo[c][1,2,5]thiadiazole-5-carbaldehyde 

Relevant articles and documents

N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-substituted-3,4-(fused 5-ring)-5-phenyl-pyrrolidin-2-one compounds (also referred to herein as "FRPPO compounds"), that, inter alia, inhibit glutaminyl-peptide cyclotransferase-like (isoQC) enzyme and/or glutaminyl-peptide cyclotransferase (QC) enzyme (e.g., inhibit or reduce or block the activity or function of isoQC and/or QC enzyme). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit isoQC and/or QC enzyme; to treat disorders that are ameliorated by the inhibition of isoQC and/or QC enzyme; to treat cancer, atherosclerosis, fibrotic diseases, infectious diseases, Alzheimer's disease, etc.

Cytotoxic activities and metabolic studies of new combretastatin analogues

A new series of combretastatin analogues with B-ring modifications were synthesized and evaluated for their cytotoxicity against one endothelial (HUVEC) and three tumor cell lines, e.g., the LoVo colon, the PC-3 prostate, and the U373 glioma cancer models. These new combretastatin analogues showed differential cytotoxic activities, cis derivatives 13 5-(2-Z-trimethoxyphenylethenyl)benzo[1,2-c]1,2,5-oxadiazole N 1-oxide and 14 5-(2-Z-trimethoxyphenylethenyl)benzo[1,2,5]thiadiazole exhibiting interesting cytotoxicity both on endothelial and on tumor cells. Unlike the cis benzofurazan 12 5-(2-Z-trimethoxyphenylethenyl)benzo[1,2-c]1,2,5-oxadiazole, induction of apoptosis by 13 appeared to be through caspase-3 activation. Metabolic investigations showed a positive correlation between highly metabolized compounds and cytotoxic activity, suggesting that highly cytotoxic derivatives may act as pro-drug via a reductive metabolization to more active metabolites.

NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.