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304-59-6

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304-59-6 Usage

Description

Potassium sodium tartrate is a double salt first prepared (in about 1675) by an apothecary, Pierre Seignette, of La Rochelle, France. As a result the salt was known as Seignette's salt or Rochelle salt. Rochelle salt is not to be confused with rock salt, which is simply the mineral form of sodium chloride. Potassium sodium tartrate and mono potassium phosphate were the first materials discovered to exhibit piezo electricity. It is a colorless to blue - white salt crystallizing in the orthorhombic system. Its molecular formula is KNaC4H4O6·4H2O. It is slightly soluble in alcohol but more completely soluble in water. It has a specific gravity of about 1.79, a melting point of approximately 75°C, and has a saline, cooling taste. As a food additive, its E number is E337. It has been used medicinally as a laxative. It has also been used in the process of silvering mirrors. It is an ingredient of Fehling's solution, formerly used in the determination of reducing sugars in solutions.

Chemical Properties

often supplied as a colourless aqueous solution

Uses

Different sources of media describe the Uses of 304-59-6 differently. You can refer to the following data:
1. Sodium Potassium Tartrate is a buffer and sequestrant that is the salt of i, (+)–tartaric acid. It has a solubility in water of 1 g in 1 ml. It is also termed rochelle salt and potassium sodium tartrate.
2. Potassium Sodium Tartrate Solution is a chelator used for research purposes.

Preparation

Potassium sodium tartrate, (KNaC4H4O6) may be prepared by adding 0.5 mole sodium carbonate to heated solution containing 1 mole potassium bitartrate(KHC4H5O6). (1M KHC4H4O6 : 0.5M Na2CO3). The solution is filtered while hot. This solution is then dried to precipitate solid potassium sodium tartrate, as small crystallites. Larger crystals of Rochelle salt have been grown under conditions of reduced gravity and convection on board Skylab .

Definition

ChEBI: The organic sodium and potassium salt of L-tartaric acid (mol ratio 1:1:1).

Flammability and Explosibility

Notclassified

Purification Methods

Recrystallise it from distilled water (1.5mL/g) by cooling to 0o. [Beilstein 3 IV 1223.]

Check Digit Verification of cas no

The CAS Registry Mumber 304-59-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 304-59:
(5*3)+(4*0)+(3*4)+(2*5)+(1*9)=46
46 % 10 = 6
So 304-59-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O6.K.Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2

304-59-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name potassium sodium L-tartrate

1.2 Other means of identification

Product number -
Other names SodiumPotassiumTartarate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:304-59-6 SDS

304-59-6Synthetic route

(+)-(2R,3R)-{3-Ethyl-3-[2-methoxy-6-(trimethylsilanyl)pyridin-4-yl]-oxiranyl}-methanol

(+)-(2R,3R)-{3-Ethyl-3-[2-methoxy-6-(trimethylsilanyl)pyridin-4-yl]-oxiranyl}-methanol

Rochelle's salt
304-59-6

Rochelle's salt

(Z)-3-[2-methoxy-3-methoxymethoxymethyl-6-(trimethylsilanyl)pyridin-4-yl]pent-2-en-1-ol
412046-42-5

(Z)-3-[2-methoxy-3-methoxymethoxymethyl-6-(trimethylsilanyl)pyridin-4-yl]pent-2-en-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether99%
diethyl ether
60-29-7

diethyl ether

Rochelle's salt
304-59-6

Rochelle's salt

3-butyl-2-hepten-1-ol
163267-92-3

3-butyl-2-hepten-1-ol

Conditions
ConditionsYield
In toluene99%
diethyl ether
60-29-7

diethyl ether

diisobutylaluminium hydride
1191-15-7

diisobutylaluminium hydride

Rochelle's salt
304-59-6

Rochelle's salt

3-butyl-2-hepten-1-ol
163267-92-3

3-butyl-2-hepten-1-ol

Conditions
ConditionsYield
In toluene99%
Rochelle's salt
304-59-6

Rochelle's salt

p-(trans-5-butyl-1,3-dioxan-2-yl)benzonitrile
74240-65-6

p-(trans-5-butyl-1,3-dioxan-2-yl)benzonitrile

p-(trans-5-butyl-1,3-dioxan-2-yl)benzaldehyde

p-(trans-5-butyl-1,3-dioxan-2-yl)benzaldehyde

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene98.3%
water
7732-18-5

water

Rochelle's salt
304-59-6

Rochelle's salt

methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate
213250-62-5

methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate

2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol
213250-63-6

2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol

Conditions
ConditionsYield
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; toluene97%
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; toluene97%
Rochelle's salt
304-59-6

Rochelle's salt

methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate
213250-62-5

methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate

2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol
213250-63-6

2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol

Conditions
ConditionsYield
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; water; toluene97%
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; water; toluene97%
[1-(Methoxy-methyl-carbamoyl)-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

[1-(Methoxy-methyl-carbamoyl)-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

Rochelle's salt
304-59-6

Rochelle's salt

[1-Formyl-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

[1-Formyl-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether; water84%
[1R-[1β(1R*,2E,4S*),[4S*],3aα,7aβ]]-Octahydro-7a -methyl-1-[1,4-dimethyl-4-[(2,24-trimethyl-1,3-dioxolan-4-yl)-2-butenyl]-4H-inden-4 -one

[1R-[1β(1R*,2E,4S*),[4S*],3aα,7aβ]]-Octahydro-7a -methyl-1-[1,4-dimethyl-4-[(2,24-trimethyl-1,3-dioxolan-4-yl)-2-butenyl]-4H-inden-4 -one

[3S-(3α,5β,Z)]-2-[2-methylene-3,5 bis-[(1,1-dimethylethyl)dimethylsilyloxy] cyclohexylidene]ethyldiphenylphosphine oxide

[3S-(3α,5β,Z)]-2-[2-methylene-3,5 bis-[(1,1-dimethylethyl)dimethylsilyloxy] cyclohexylidene]ethyldiphenylphosphine oxide

1α,25(S),26-trihydroxycholecalciferol

1α,25(S),26-trihydroxycholecalciferol

potassium carbonate
584-08-7

potassium carbonate

Rochelle's salt
304-59-6

Rochelle's salt

1α,25S,26-trihydroxyergocalciferol

1α,25S,26-trihydroxyergocalciferol

Conditions
ConditionsYield
With n-butyllithium; potassium hydrogencarbonate In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate83%
diisobutylaluminum hydride (Dibal-H)

diisobutylaluminum hydride (Dibal-H)

(S)-γ-pivaloyloxymethyl-γ-butyrolactone

(S)-γ-pivaloyloxymethyl-γ-butyrolactone

dichloromethane
75-09-2

dichloromethane

Rochelle's salt
304-59-6

Rochelle's salt

2-(R,S)-Hydroxy-5-(S)-(pivaloyloxymethyl)tetrahydrofuran
145164-89-2

2-(R,S)-Hydroxy-5-(S)-(pivaloyloxymethyl)tetrahydrofuran

Conditions
ConditionsYield
In tetrahydrofuran; methanol82%
3,3-diphenyl-2-propenal
1210-39-5

3,3-diphenyl-2-propenal

Rochelle's salt
304-59-6

Rochelle's salt

3,3-diphenylprop-2-en-1-ol
4801-14-3

3,3-diphenylprop-2-en-1-ol

Conditions
ConditionsYield
With diisobutylaluminium hydride In methanol; toluene80%
With diisobutylaluminium hydride In methanol; toluene80%
ethyl 5-iodo-4-(methylsulfonamido)-2-(methylthio)benzoate
1456693-17-6

ethyl 5-iodo-4-(methylsulfonamido)-2-(methylthio)benzoate

Rochelle's salt
304-59-6

Rochelle's salt

N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide
1456693-19-8

N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene80%
With diisobutylaluminium hydride In toluene80%
With diisobutylaluminium hydride In toluene80%
With diisobutylaluminium hydride In toluene80%
ethyl 2-[2-(1-ethoxyethoxy)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
198774-56-0

ethyl 2-[2-(1-ethoxyethoxy)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide

Rochelle's salt
304-59-6

Rochelle's salt

2-(2-Hydroxyethyl)-3-hydroxymethyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
198774-57-1

2-(2-Hydroxyethyl)-3-hydroxymethyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

Conditions
ConditionsYield
With hydrogenchloride; diisobutylaluminium hydride In water; acetone79%
cis-3-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-but-2-enoic acid ethyl ester

cis-3-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-but-2-enoic acid ethyl ester

Rochelle's salt
304-59-6

Rochelle's salt

trans-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-but-2-enyl]-carbamic acid tert-butyl ester
558443-43-9

trans-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-but-2-enyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With diisobutylaluminium hydride In dichloromethane77%
3-(3-benzyloxy-phenyl)-benzonitrile
893736-89-5

3-(3-benzyloxy-phenyl)-benzonitrile

Rochelle's salt
304-59-6

Rochelle's salt

3-(3-benzyloxy-phenyl)-benzaldehyde
893736-16-8

3-(3-benzyloxy-phenyl)-benzaldehyde

Conditions
ConditionsYield
With diisobutylaluminium hydride In tetrahydrofuran; hexane; water75%
S(+)-phenylglycine

S(+)-phenylglycine

Rochelle's salt
304-59-6

Rochelle's salt

benzoyl chloride
98-88-4

benzoyl chloride

N-(2-hydroxy-1-phenylethyl)benzamide
96392-53-9

N-(2-hydroxy-1-phenylethyl)benzamide

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium chloride In tetrahydrofuran; methanol; dichloromethane; water62%
carbon dioxide
124-38-9

carbon dioxide

ethyl(diethylphosphono)(fluoro)acetate
2356-16-3

ethyl(diethylphosphono)(fluoro)acetate

(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester
1393802-40-8

(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

ammonium chloride

ammonium chloride

Rochelle's salt
304-59-6

Rochelle's salt

(R)-ethyl 5-((R)-1,1-dimethylethylsulfinamido)-2,4,4-trifluoro-5-(2-fluorophenyl)-hex-2-enoate

(R)-ethyl 5-((R)-1,1-dimethylethylsulfinamido)-2,4,4-trifluoro-5-(2-fluorophenyl)-hex-2-enoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; SiO2 In water; ethyl acetate; toluene; acetonitrile60%
4-benzylthio-2,3,5,6-tetrahydro-4-nitromethyl-4H-pyran
133762-55-7

4-benzylthio-2,3,5,6-tetrahydro-4-nitromethyl-4H-pyran

Rochelle's salt
304-59-6

Rochelle's salt

4-aminomethyl-4-benzylthio-2,3,5,6-tetrahydro-4H-pyran
133762-56-8

4-aminomethyl-4-benzylthio-2,3,5,6-tetrahydro-4H-pyran

Conditions
ConditionsYield
In water; isopropyl alcohol59%
(1R,3R,5R) Methyl [3,5-Bis(tert.-butyldimethylsilyloxy)-1-hydroxycyclohexane carboxylate

(1R,3R,5R) Methyl [3,5-Bis(tert.-butyldimethylsilyloxy)-1-hydroxycyclohexane carboxylate

Rochelle's salt
304-59-6

Rochelle's salt

1-hydroxy-1-hydroxymethylcyclohexane

1-hydroxy-1-hydroxymethylcyclohexane

Conditions
ConditionsYield
With diisobutylaluminium hydride In ethyl acetate; toluene59%
(2R,4R)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-E-(2-carbomethoxy-vinyl)uracil

(2R,4R)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-E-(2-carbomethoxy-vinyl)uracil

Rochelle's salt
304-59-6

Rochelle's salt

(2S,4S)-5-(3-hydroxypropenyl)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]uracil

(2S,4S)-5-(3-hydroxypropenyl)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]uracil

Conditions
ConditionsYield
With diisobutylaluminium hydride In methanol; hexane; toluene56%
Rochelle's salt
304-59-6

Rochelle's salt

methyl benzo-2,1,3-thiadiazole-5-carboxylate

methyl benzo-2,1,3-thiadiazole-5-carboxylate

2,1,3-benzothiadiazol-5-ylmethanol
89795-51-7

2,1,3-benzothiadiazol-5-ylmethanol

Conditions
ConditionsYield
In diethyl ether; ethyl acetate; Petroleum ether47%
benzyl(2-methyl-1-nitropropan-2-yl)sulfane
105780-12-9

benzyl(2-methyl-1-nitropropan-2-yl)sulfane

Rochelle's salt
304-59-6

Rochelle's salt

2-benzylthio 2-methyl propylamine
59681-09-3

2-benzylthio 2-methyl propylamine

Conditions
ConditionsYield
In water; isopropyl alcohol46%

304-59-6Upstream product

304-59-6Relevant articles and documents

PPARo ACTIVATOR

-

, (2022/02/11)

The present invention provides a PPARδ activator containing a novel PPARδ agonist (peroxisome proliferator-activated receptor δ) as an active ingredient, and an exercise tolerance-improving agent containing the same as an active ingredient. The present invention is a PPARδ activator containing a guanidine derivative or a biguanidine derivative as an active ingredient, wherein the PPARδ activator activates transcriptional activity of PPARδ, and the guanidine derivative and the biguanidine derivative are capable of fitting within a PPARδ ligand binding pocket in a state where a guanidino group or a biguanidino group forms a hydrogen bond with amino acid residues corresponding to each of the 413th histidine, 287th histidine, 253rd threonine and the 437th tyrosine of human PPARδ, among amino acid residues constituting an interior surface of the ligand binding pocket; and is an exercise tolerance-improving agent containing the PPARδ activator as an active ingredient.

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