89795-76-6Relevant academic research and scientific papers
Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker
Congreve, Miles S.,Kay, Corinne,Scicinski, Jan J.,Ley, Steven V.,Williams, Geoffrey,Murray, Peter J.,McKeown, Stephen C.,Watson, Stephen P.
, p. 4153 - 4156 (2003)
The development of a versatile amine releasing linker based on the modified o-nitrobenzene sulfonamide protective group is described. This new N-Boc-o-nitrobenzenesulfonamide (Boc-ONBS) linker enables the elaboration on resin of primary and secondary amines by sequential substitution of the sulfonamide moiety using the Mitsunobu reaction. A 16-member array of secondary and Boc protected primary amines was then prepared using this linker.
Non-peptidic angiotensin-II-receptor-antagonists
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, (2008/06/13)
Novel compounds having the formula STR1 wherein R 1, R 2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
