89804-60-4

Upstream product

• 7339-53-9 methyl hydrazine hydrochloride 
• 89804-55-7 N-(phenylthioxomethyl)-4-(trifluoromethyl)benzamide 
• 2227-79-4 benzenecarbothioamide 
• 288254-83-1 2-(4-trifluoromethylbenzoyl)benzhydrazide 
• 613-94-5 benzoic acid hydrazide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 89804-59-1 5-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole 
• 74-88-4 methyl iodide 
• 471910-35-7 3-(4-trifluoromethylphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 20743-49-1 2-methyl-5-phenyl-2H-tetrazole 
• 455-18-5 4-CF₃C₆H₄CN 

Relevant academic research and scientific papers

Regioselectivity in the thermal rearrangement of unsymmetrical 4-methyl-4H-1,2,4-triazoles to 1-methyl-1H-1,2,4-triazoles

The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps.

Synthesis of 1,2,4-Triazoles and 1,2,4-Oxadiazoles

Monothiodiacylamines reacted regiospecifically with hydrazines and hydroxylamine to give substituted 1,2,4-triazoles and 1,2,4-oxadiazoles in excellent yields.