89808-15-1

Basic information

• Product Name: 2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)
• Synonyms: 2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)
• CAS NO: 89808-15-1
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.15516
• Product Categories: PYRIMIDINE
• Mol File: 89808-15-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)(89808-15-1)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)(89808-15-1)

Safety Data

• Hazardous Substances Data: 89808-15-1(Hazardous Substances Data)

Usage

Chemical Family

Pyrimidine

Derivative

Yes, with two methyl groups attached at positions 4 and 6

Functional Group

Oxime

Molecular Structure

2(1H)-Pyrimidinone, 4,6-dimethyl-, oxime (9CI)

Pharmaceutical Applications

Yes, as a building block in the synthesis of various drugs and bioactive molecules

Uniqueness

Unique structure and properties making it interesting for further research and development in medicinal chemistry and drug discovery.

Upstream product

• 99418-09-4 (4,6-dimethyl-pyrimidin-2-yl)-nitro-amine 
• 123-54-6 acetylacetone 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 

Downstream Products

• 120819-01-4 C₁₅H₁₅N₃O₄ 
• 120819-02-5 N-Benzoyloxy-2-chloro-N-(4,6-dimethyl-pyrimidin-2-yl)-acetamide 
• 120819-03-6 2-Chloro-N-(2,4-dichloro-benzoyloxy)-N-(4,6-dimethyl-pyrimidin-2-yl)-acetamide 
• 126382-54-5 4,6-dimethyl-2-nitrosopyrimidine 
• 126382-61-4 (4,6-Dimethyl-pyrimidin-2-yl)-phenyl-diazene 
• 120819-00-3 C₁₃H₁₁Cl₂N₃O₂ 
• 120818-99-7 C₁₃H₁₃N₃O₂ 

Relevant articles and documents

Catalytic Enantioselective Nitroso Diels-Alder Reaction

The nitroso Diels-Alder (NDA) reaction is an attractive strategy for the synthesis of 3,6-dihydro-1,2-oxazines and 1-amino-4-hydroxy-2-ene derivatives. Herein we report the Cu(I)-DTBM-Segphos catalyzed asymmetric intermolecular NDA reaction of variously substituted cyclic 1,3-dienes using highly reactive nitroso compounds derived from pyrimidine and pyridazine derivatives. In most of the cases studied, the cycloadducts were obtained in high yields (up to 99%) with very high regio-, diastereo-, and enantioselectivities (up to regioselectivity > 99:1, d.r. > 99:1, and >99% ee). As an application of this methodology, formal syntheses of conduramine A-1 and narciclasine were accomplished.

THE SYNTHESIS AND SOME REACTIONS OF CHLOROPYRIMIDINES

Several chloro-hydroxy- and amino- chloropyrimidines have been prepared.The chloro groups have been replaced by hydrogen, mercapto, or hydroxyamino substituents to give useful synthetic intermediates.