89812-52-2

Upstream product

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 128951-11-1 2-Hydroxy-4-[(E)-2-(4-methoxy-phenyl)-vinyl]-6-methylsulfanyl-benzoic acid ethyl ester 
• 128031-99-2 ethyl 3-(4-methoxystyryl)-5-methylthio furan-2-carboxylate 
• 128032-04-2 ethyl 3-<2-carbethoxy-3-(4-methoxyphenyl)cycloprop-1-yl>-5-methylthio furan-2-carboxylate 
• 130445-91-9 3-cyano-2-methyl-4-(4-methoxyphenyl)-6-<2-bis(methylthio)ethenyl>pyridine 
• 117672-09-0 5-(4-Methoxy-phenyl)-2-methylsulfanyl-pyran-4-one 
• 117672-01-2 (Z)-3-Hydroxy-2-(4-methoxy-phenyl)-5,5-bis-methylsulfanyl-penta-2,4-dienal 
• 117671-93-9 1-[(2S,3R)-3-(4-Methoxy-phenyl)-oxiranyl]-3,3-bis-methylsulfanyl-propenone 
• 137612-56-7 5-[(E)-2-(4-Methoxy-phenyl)-vinyl]-3-methylsulfanyl-isoxazole 
• 137612-70-5 3-[(E)-2-(4-Methoxy-phenyl)-vinyl]-5-methylsulfanyl-1H-pyrazole 
• 137612-41-0 3-[(E)-2-(4-Methoxy-phenyl)-vinyl]-5-methylsulfanyl-isoxazole 
• 132916-78-0 2-Acetoxy-5,5-bis(methylthio)-4-(4-methoxyphenyl)-2-cyclopenten-1-one 
• 134854-89-0 1-<2-bis(methylthio)methyleneacetyl>-2-cyano-3-(4-methoxyphenyl)cyclopropane 
• 117953-52-3 (2Z,4E)-3-Hydroxy-5-(4-methoxy-phenyl)-penta-2,4-dienoic acid methyl ester 

Relevant academic research and scientific papers

α-Aroylidineketene dithioacetal chemistry: CuI catalyzed synthesis of 2-styryl benzimidazoles enroute to regioselective hydrothiolation

Abstract Reactivity of α-aroylidineketene dithioacetals 2 was investigated to synthesize novel 2-styrylbenzimidazole derivatives 4 and their hydrothiolated product 2-(2-(methylthio)-2-arylethyl)-1H-benzo[d]imidazoles 5 has been reported. Compounds 4 and 5

Convenient one-pot multicomponent strategy for the synthesis of 6-pyrrolylpyrimidines

We have developed an easy method to construct diheteroaryls from α-aroylidineketene dithioacetals in a multicomponent manner. The reaction proceeded with high chemo/regioselectivity to yield 4-alkoxy-6-(4-aryl-1H- pyrrol-3-yl)pyrimidin-2-amines under mild

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Chemotherapy of leishmaniasis part II: Synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents

Some novel aryl substituted ketene dithioacetals 6 (a-d), 9 (a-c) and 10 (a-c) have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50mg kg-1 × 5 days.