898138-80-2

Upstream product

• 4891-38-7 phenylpropynoic acid methyl ester 
• 536-74-3 phenylacetylene 
• 615-36-1 2-bromoaniline 
• 637-44-5 phenylpropyolic acid 

Downstream Products

• 1335106-39-2 6-bromo-3-iodo-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 4679-83-8 (E)-3-(diphenylmethylene)-1-methylindolin-2-one 
• 1039396-21-8 (E)-3-((4-methoxyphenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-94-1 (Z)-3-((4-methoxyphenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-89-4 (Z)-3-((4-chlorophenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-91-8 (E)-3-((4-chlorophenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1039396-25-2 (E)-1-methyl-3-((4-nitrophenyl)(phenyl)methylene)indolin-2-one 
• 1477484-70-0 (Z)-1-methyl-3-((4-nitrophenyl)(phenyl)methylene)indolin-2-one 
• 50290-45-4 2-phenyl-10H-pyrimido<1,2-a>benzimidazol-4-one 

Relevant academic research and scientific papers

(: Z)-Selective anti-Markovnikov or Markovnikov thiol-yne-click reactions of an internal alkyne by amide hydrogen bond control

Herein, we show exclusive control of stereo and regioselective thiol-yne click (TYC) reactions of internal alkynes via amide hydrogen bond control. By exploiting appropriate hydrogen bonding interactions like N-H?S, N-H?N and C-H?O, either (Z)-selective anti-Markovnikov or Markovnikov products could be obtained for an internal alkyne, exclusively.

One-pot synthesis of a white-light emissive bichromophore operated by aggregation-induced dual emission (AIDE) and partial energy transfer

Merocyanine-triarylamine bichromophores are readily synthesized by sequentially Pd-catalyzed insertion-alkynylation-Michael-Suzuki four-component reactions. White-light emissive systems form upon aggregation in 1 : 99 and 0.1 : 99.9 vol percent CH2Cl2-cyclohexane mixtures, ascribed to aggregation-induced dual emission (AIDE) in combination with partial energy transfer between both chromophore units as supported by spectroscopic studies.

Access to 3-(2-Oxoalkyl)-azaspiro[4.5]trienones via Acid-Triggered Oxidative Cascade Reaction through Alkenyl Peroxide Radical Intermediate

Azaspiro[4.5]trienones bearing ketone side chains at the 3-position are prepared from N-alkyl-arylpropiolamides and ketones via oxidative 1,2-difunctionalization of alkynes. The cascade sequence starts with the generation of alkenyl peroxide intermediates

Copper-Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using Cyanamide as a Building Block

An efficient and practical copper-catalyzed domino synthesis of benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones has been developed. The protocol uses N-(2-halophenyl)-3-alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.

Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)oxindoles Using Microwave Irradiation

We developed a rapid and efficient microwave-assisted tandem reaction for the synthesis of 3-(diarylmethylene)oxindoles. Three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions) were combined under microwave irradiation conditions to produce 3-(diarylmethylene)oxindoles from simple propiolamides, aryl iodides, and arylboronic acids. The addition of Ag3PO4 enhanced the yield and stereoselectivity of the tandem reaction significantly.

Synthesis of 3-(diarylmethylene)oxindoles via a palladium-catalyzed one-pot reaction: Sonogashira-heck-suzuki-miyaura combined reaction

A novel one-pot reaction for the synthesis of 3-(diarylmethylene)oxindoles is described. The reaction involves the successive combination of three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions). This method enables the rapid synthesis of various 3-(diarylmethylene)oxindoles from simple propiolamides. The addition of silver salts dramatically enhanced the E/Z stereoselectivity of the reaction. Georg Thieme Verlag Stuttgart, New York.