898138-80-2

Upstream product

• 615-36-1 2-bromoaniline 
• 637-44-5 phenylpropyolic acid 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 536-74-3 phenylacetylene 

Downstream Products

• 1335106-39-2 6-bromo-3-iodo-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 4679-83-8 (E)-3-(diphenylmethylene)-1-methylindolin-2-one 
• 1039396-21-8 (E)-3-((4-methoxyphenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-94-1 (Z)-3-((4-methoxyphenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-89-4 (Z)-3-((4-chlorophenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1416431-91-8 (E)-3-((4-chlorophenyl)(phenyl)methylene)-1-methylindolin-2-one 
• 1039396-25-2 (E)-1-methyl-3-((4-nitrophenyl)(phenyl)methylene)indolin-2-one 
• 1477484-70-0 (Z)-1-methyl-3-((4-nitrophenyl)(phenyl)methylene)indolin-2-one 
• 50290-45-4 2-phenyl-10H-pyrimido<1,2-a>benzimidazol-4-one 

Relevant academic research and scientific papers

(: Z)-Selective anti-Markovnikov or Markovnikov thiol-yne-click reactions of an internal alkyne by amide hydrogen bond control

Herein, we show exclusive control of stereo and regioselective thiol-yne click (TYC) reactions of internal alkynes via amide hydrogen bond control. By exploiting appropriate hydrogen bonding interactions like N-H?S, N-H?N and C-H?O, either (Z)-selective anti-Markovnikov or Markovnikov products could be obtained for an internal alkyne, exclusively.

One-pot synthesis of a white-light emissive bichromophore operated by aggregation-induced dual emission (AIDE) and partial energy transfer

Merocyanine-triarylamine bichromophores are readily synthesized by sequentially Pd-catalyzed insertion-alkynylation-Michael-Suzuki four-component reactions. White-light emissive systems form upon aggregation in 1 : 99 and 0.1 : 99.9 vol percent CH2Cl2-cyclohexane mixtures, ascribed to aggregation-induced dual emission (AIDE) in combination with partial energy transfer between both chromophore units as supported by spectroscopic studies.

Access to 3-(2-Oxoalkyl)-azaspiro[4.5]trienones via Acid-Triggered Oxidative Cascade Reaction through Alkenyl Peroxide Radical Intermediate

Azaspiro[4.5]trienones bearing ketone side chains at the 3-position are prepared from N-alkyl-arylpropiolamides and ketones via oxidative 1,2-difunctionalization of alkynes. The cascade sequence starts with the generation of alkenyl peroxide intermediates

Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)oxindoles Using Microwave Irradiation

We developed a rapid and efficient microwave-assisted tandem reaction for the synthesis of 3-(diarylmethylene)oxindoles. Three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions) were combined under microwave irradiation conditions to produce 3-(diarylmethylene)oxindoles from simple propiolamides, aryl iodides, and arylboronic acids. The addition of Ag3PO4 enhanced the yield and stereoselectivity of the tandem reaction significantly.

Copper-Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using Cyanamide as a Building Block

An efficient and practical copper-catalyzed domino synthesis of benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones has been developed. The protocol uses N-(2-halophenyl)-3-alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.

Synthesis of 3-(diarylmethylene)oxindoles via a palladium-catalyzed one-pot reaction: Sonogashira-heck-suzuki-miyaura combined reaction

A novel one-pot reaction for the synthesis of 3-(diarylmethylene)oxindoles is described. The reaction involves the successive combination of three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions). This method enables the rapid synthesis of various 3-(diarylmethylene)oxindoles from simple propiolamides. The addition of silver salts dramatically enhanced the E/Z stereoselectivity of the reaction. Georg Thieme Verlag Stuttgart, New York.