89822-85-5

Upstream product

• 116-17-6 triisopropyl phosphite 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 1809-20-7 diisopropyl hydrogenphosphonate 
• 100-14-1 4-nitrobenzyl chloride 
• 51421-21-7 4-nitrobenzylhydrazine 

Downstream Products

• 98934-26-0 [(Z)-2-Dimethylamino-1-(4-nitro-phenyl)-vinyl]-phosphonic acid diisopropyl ester 
• 98934-38-4 [(Z)-2-Hydroxy-1-(4-nitro-phenyl)-vinyl]-phosphonic acid diisopropyl ester 
• 98934-63-5 [(Z)-1-(4-Amino-phenyl)-2-dimethylamino-vinyl]-phosphonic acid diisopropyl ester 

Relevant academic research and scientific papers

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

ISOXAZOLE DERIVATIVES

A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of th

REACTIVITY OF THE ACIDS OF TRIVALENT PHOSPHORUS AND THEUR DERIVATIVES. PART II. THE REACTION OF TRIVALENT PHOSPHORUS ACID SALTS WITH THE BENZYLIC HALIDES SYSTEM

The reaction of the benzylic halides systems with sodium dialkylphosphites as well as the sodium salt of dibenzylphosphine oxide in THF and alcohols as the solvents is described.According to the constitution of the starting materials, the formation of the P-C bond, dehalogenation or dimerization occurs.Probable mechanisms namely SET and X-philic substitution are discussed.Key words: Benzylic halides system, dialkylphosphites, dibenzylphosphine oxide, Michaelis-Becker reaction, X-philic substitution.

DIALKYL FORMYL-1 METHYLPHOSPHONATES α-FONCTIONNELS-II. PREPARATION PAR VOIE THERMIQUE ET TRANSFORMATION EN HETEROCYCLES α-PHOSPHONIQUES

The thermal condensation of functional phosphonates bearing strongly withdrawing groups (RO)2P(O)CH2Z 1 with dimethylformamide dimethyl acetal gives corresponding β-functional, β-phosphonic enamines (RO)2P(O)C(Z)=CHNMe2 2.Acid or basic hydrolysis of the enamines frequently gives the free aldehyde (RO)2P(O)CH(Z)-CHO 3.We show that the enamines can be used with success for the synthesis of heterocycles like, pyrazoles 4, pyrimidines 5, benzodiazepine 6 or indole 7, all of them substituted with a phosphonate group.