898225-48-4Relevant academic research and scientific papers
β-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product
Grotenbreg, Gijsbert M.,Buizert, Annelies E. M.,Llamas-Saiz, Antonio L.,Spalburg, Emile,Van Hooft, Peter A. V.,De Neeling, Albert J.,Noort, Daan,Van Raaij, Mark J.,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Overhand, Mark
, p. 7559 - 7565 (2007/10/03)
This paper describes the design and synthesis of gramicidin S (GS) analogues 10a-c containing arylated sugar amino acids (SAAs) as a replacement of one of the two DPhe-Pro β-turn regions. The cyclic, amphiphilic peptides adopt a β-sheet conform
