89838-96-0Relevant articles and documents
CoA-IT and PAF inhibitors
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, (2008/06/13)
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
Triphenylimidazolyloxyalkanoic acids and their derivatives and a process for the treatment of thromboembolic, inflammatory and/or atheriosclerotic diseases
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, (2015/03/06)
The invention relates to new triphenylimidazolyloxyalkanoic acids of the general formula I STR1 and a process for the treatment of thromboembolic, inflammatory and/or atherosclerotic diseases in humans by using the same.