89840-80-2

Usage

Uses

Used in Dye and Pigment Manufacturing:
4-Nitro-benzenesulfonic acid isobutylamide is used as an intermediate in the production of dyes and pigments for various applications, including textiles, plastics, and paints. Its chemical structure contributes to the color and stability of these products.
Used in Pharmaceutical Industry:
4-Nitro-benzenesulfonic acid isobutylamide is used as a building block in the synthesis of certain pharmaceuticals. Its unique chemical properties allow it to be incorporated into the development of new drugs, potentially enhancing their efficacy and safety.
Used in Chemical Research:
In the field of chemical research, 4-Nitro-benzenesulfonic acid isobutylamide serves as a valuable compound for studying the properties and reactions of sulfonamide derivatives. This can lead to advancements in understanding their behavior and potential applications in various chemical processes.

Upstream product

• 78-81-9 isobutylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 240416-29-9 [Isobutyl-(4-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester 
• 179174-21-1 N-isobutyl-N-(4-nitrophenylsulfonyl)aminoacetic acid 
• 179173-94-5 N-isobutyl-N-{2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-4-nitro-benzenesulfonamide 
• 161314-36-9 N-hydroxy-2-[[4-nitrobenzenesulfonyl](isobutyl)amino]acetamide 
• 251105-80-3 N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride 
• 169280-56-2 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 
• 191226-98-9 [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester 
• 53668-36-3 4-amino-N-isobutylbenzenesulfonamide 

Relevant academic research and scientific papers

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HTS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial β-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure-activity relationships of these compounds were explored.

From ynamides to highly substituted benzo[b]furans: Gold(I)-catalyzed 5-endo-dig-cyclization/rearrangement of alkylic oxonium intermediates

A series of arylynamides with alkyloxy groups at the ortho position of the aryl group was prepared through a short alkylation/cross-coupling/amidation sequence. The gold-catalyzed conversion of these substrates combined both C-O and C-C formation steps, thus providing benzofurans with amine functionalities at the 2-position and alkyl groups at the 3-position. Cross-over experiments showed that the alkyl-migration step was an intermolecular process. X-ray crystal-structure analysis of two of the products supported our structural assignment. In some cases, the corresponding benzofurans without the alkyl group at the 3-position were obtained as side-products, which were formed through a competing protodeauration process. Golden touch: Arylynamides with o-alkyloxy groups were prepared through an alkylation/cross-coupling/amidation sequence. Their Au-catalyzed conversion provided benzofurans with amine groups at the 2-position and alkyl groups at the 3-position. Copyright

PROCESS FOR THE PREPARATION OF SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS

The present invention relates to a process for the preparation of sulfonamides useful as retroviral protease inhibitors.

Piperidine derivatives with PAF antagonist activity

Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their prepara

Discovery of CGS 27023A, a non, peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

Structure-activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined by taking advantage of a concise synthesis that allowed diverse functionality to be explored at each position in a template. An ex vivo rat model and an in vivo rabbit model of stromelysin-induced cartilage degradation were used to further optimize these analogs for oral activity and duration of action. The culmination of these modifications resulted in CGS 27023A, a potent, orally active stromelysin inhibitor that blocks the erosion of cartilage matrix.