89851-63-8Relevant academic research and scientific papers
Microwave-assisted beckmann rearrangement: Convenient synthesis of 1,3-diaza-bicyclo[3.2.2]nonane
Curtis, Michael P.,Bunnelle, William H.,Pagano, Thomas G.,Gopalakrishnan, Murali,Faghih, Ramin
, p. 321 - 326 (2007/10/03)
Small heterocyclic amines such as 1,3-diaza-bicyclo[3.2.2]nonane are known to be key components of biologically active molecules. A convenient synthesis of this compound utilizing a key Beckmann rearrangement of (Z)-1-aza-bicyclo[2.2. 2]octan-3-one oxime (6) with conc. H2SO4 under microwave irradiation was achieved. The desired compound (1) was obtained in 20% yield overall. Copyright Taylor & Francis LLC.
