898547-01-8

Upstream product

• 898547-00-7 (2S,3S)-3-(4-(benzyloxy)-3-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)-2-methylpropan-1-ol 
• 898546-99-1 (S)-4-benzyl-3-((2R,3S)-3-(4-(benzyloxy)-3-methoxyphenyl)-3-hydroxy-2-methylpropanoyl)oxazolidin-2-one 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 898547-02-9 (2R,3S,4S)-4-(4-(benzyloxy)-3-methoxyphenyl)-4-((tert-butyldimethylsilyl)oxy)-2,3-dimethylbutan-1-ol 
• 898547-03-0 (3R,4S,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-dihydro-furan-2-one 
• 898547-05-2 5-[(2S,3S,4S,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-benzo[1,3]dioxole 
• 1296147-78-8 C₃₃H₄₄O₆Si 
• 1296147-82-4 (1R,2R,3S,4S)-1-(benzo[d][1,3]dioxol-5-yl)-4-(4-(benzyloxy)-3-methoxyphenyl)-2,3-dimethylbutane-1,4-diol 
• 1072281-38-9 C₂₇H₂₈O₅ 
• 1296147-83-5 5-((2R,3R,4S,5S)-5-(4-(benzyloxy)-3-methoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl)benzo[d][1,3]dioxole 
• 114488-90-3 machilin F 
• 1072442-89-7 4-((2S,3S,4S,5R)-5-Benzo[1,3]dioxol-5-yl-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenol 
• 1072281-37-8 (2R,3S,4S)-1-(benzo[d][1,3]dioxol-5-yl)-4-(4-(benzyloxy)-3-methoxyphenyl)-4-((tert-butyldimethylsilyl)oxy)-2,3-dimethylbutan-1-one 
• 1072281-54-9 C₃₃H₄₄O₆Si 
• 1072442-90-0 C₂₀H₂₂O₅ 

Relevant academic research and scientific papers

Systematic Asymmetric Synthesis of All Diastereomers of (-)-Talaumidin and Their Neurotrophic Activity

(-)-Talaumidin (1), a 2,5-biaryl-3,4-dimethyltetrahydrofuran lignan isolated from Aristolochia arcuata Masters, shows significant neurite-outgrowth promotion and neuroprotection in primary cultured rat cortical neurons and in NGF-differentiated PC12 cells

Asymmetric synthesis of (+)-machilin f by unusual stereoselective mitsunobu reaction

First synthesis of (+)-machilin F (1c) has been achieved in 16 steps as part of systematic synthetic studies on (-)-talaumidin (1) and its stereoisomers. The 2,3,4,5-tetrasubstituted tetrahydrofuran with the (2S,3S,4S,5S)-configuration has been constructe

First enantioselective synthesis of (-)-talaumidin, a neurotrophic diaryltetrahydrofuran-type lignan

The first enantioselective total synthesis of a neurotrophic (-)-talaumidin (1) is described in 16 steps from 4-benzyloxy-3-methoxybenzaldehyde in ca. 10.7% overall yield, and thus has established the absolute configurations of the four stereogenic center