898559-23-4

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Bromo-2-iodoquinoline is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with improved therapeutic properties.
Used in Organic Synthesis:
3-Bromo-2-iodoquinoline is utilized as a building block in organic synthesis reactions, enabling the creation of novel molecules with tailored characteristics for specific applications.
Used in Medicinal Chemistry and Drug Discovery:
3-Bromo-2-iodoquinoline is employed as a valuable chemical in the field of medicinal chemistry and drug discovery, where its unique structure and properties can be leveraged to explore new avenues for therapeutic interventions.
Used in Research and Scientific Studies:
3-Bromo-2-iodoquinoline is a potentially useful chemical for researchers and scientists working in the fields of chemistry and pharmaceuticals, providing a foundation for innovative research and the advancement of scientific knowledge.

Upstream product

• 5332-24-1 3-bromoquinoline 
• 101870-60-4 3-bromo-2-chloro-quinoline 
• 939-16-2 3-bromoquinolin-2-one 
• 22615-00-5 3-bromoquinoline N-oxide 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 109130-61-2 10-benzyl-10H-indolo[3,2-b]quinoline 
• 1620749-79-2 3-bromo-2-(trifluoromethyl)quinoline 

Relevant academic research and scientific papers

A concise synthesis of indoloquinoline skeletons applying two consecutive Pd-catalyzed reactions

The indoloquinoline alkaloids cryptolepine (1), neocryptolepine (2), isocryptolepine (3), and isoneocryptolepine (4) are important tools in traditional medicine. Now, their precursors 1a-4a were synthesized in two steps starting from the corresponding bromo-iodoquinolines. Our strategy is based on palladium-catalyzed reactions, applying regioselective Buchwald-Hartwig amination on 2,3- and 3,4-dihaloquinolines followed by an intramolecular Heck-type reaction. Both steps were carried out under microwave irradiation.

Tmp4Zr: An atom-economical base for the metalation of functionalized arenes and heteroarenes

Zirconium bases reach lots of places: Only 25 % of zirconium metal is required for the metalation of various functionalized aromatic compounds and heterocycles. All four 2,2,6,6-tetramethylpiperidyl (tmp) groups of the new base tmp4Zr.4 MgClsu

PREPARATION AND USE OF MAGNESIUM AMIDES

The present application relates to mixed Mg/Li amides of the general formula R1R2N-Mg-NR3R4.zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R4 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n = 3 or 4 and Hal is selected from Ci, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RxCO2; an alcoholate of the general formula ORx; a thiolate of the general formula SRx; RxP(O)O2; or SCORx; or SCSRx; OnSRx, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z > 1; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

Preparation and use of magnesium amides

The present application relates to mixed Mg/Li amides of the general formula ???????? R1R2N-MgX·zLiY?????(I), wherein R1, R2 and R3 independently are selected from substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, and, for R1 and R2 only, the silyl derivatives thereof; one of R1 and R2 may be H; or R1 and R2 together can be part of a cyclic or polymeric structure; X and Y independently are selected amongst others from the group consisting of F; Cl; Br; I; CN; SCN; NCO; and z > 0, as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

Mixed Mg/Li amides of the type R2NMgCl·LiCl as highly efficient bases for the regioselective generation of functionalized aryl and heteroaryl magnesium compounds

(Chemical Equation Presented) Two are better than one: Mixed lithium-magnesium complexes of the type R2NMgCl·LiCl are kinetically highly active bases that convert a range of polyfunctional aromatic and heteroaromatic substrates into the corresponding magnesiated derivatives with high regioselectivity.