89875-37-6Relevant academic research and scientific papers
5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry
Arico, Fabio,Toniolo, Umberto,Tundo, Pietro
experimental part, p. 58 - 61 (2012/03/26)
Aliphatic and aromatic 1,4-bifunctional compounds bearing a primary alcoholic function and an amine can be efficiently cyclised with dimethyl carbonates in the presence of a base to achieve 5-membered N-heterocyclic compounds. This novel synthetic pathway
Palladium-catalyzed sp3 C-H activation of simple alkyl groups: Direct preparation of indoline derivatives from N-alkyl-2-bromoanilines
Watanabe, Toshiaki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
supporting information; experimental part, p. 1759 - 1762 (2009/04/12)
The sp3 C-H activation of a simple alkyl group catalyzed by palladium(O) provides a novel and convenient strategy for the synthesis of various indolines from simple precursors, such as N-alkyl-2-bromoanilines. This study demonstrates that assisting moieties In the substrate such as a pyridine or quaternary carbon are not always necessary for sp3 C-H activation.
