898766-74-0Relevant academic research and scientific papers
Preparation method of 2-diethylamino-1-methylethyl-7-cyclohexyl-7-oxoheptanoate
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Paragraph 0022; 0053; 0054, (2017/11/04)
The invention provides a compound 2-diethylamino-1-methylethyl-7-cyclohexyl-7-oxo-heptanoate (1) and a synthesis method thereof. The compound 1 adopts a structural formula as shown in the specification. The invention further provides the application of the compound 1 as an impurity reference substance for monitoring synthesis of an active pharmaceutical ingredient of rociverine. By taking cycloheptanone as a starting material, the compound 1 is synthesized through a four-step reaction; the obtained product is simple in posttreatment of each step, the product is convenient and easy to obtain, the compound 1 is suitable for being synthesized on a large scale, and a relevant substance or the impurity reference substance are provided for quality research on the synthesis of the active pharmaceutical ingredient of the rociverine.
