898768-12-2

Upstream product

• 625-36-5 2-chloropropionyl chloride 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 

Downstream Products

• 1422510-87-9 methyl (9R,14S)-14-[(6R)-6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-17-cyano-5-[(methoxycarbonyl)amino]-8-(trifluoroacetyl)-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaene-9-carboxylate 
• 1422510-86-8 methyl (9R,14S)-14-{[(3R)-3-(3-chlorophenyl)-3-hydroxypropyl]amino}-17-cyano-5-[(methoxycarbonyl)amino]-8-(trifluoroacetyl)-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaene-9-carboxylate 
• 1422507-94-5 methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride 
• 1422510-77-7 methyl N-[(12E,15S)-15-{[3-(3-chlorophenyl)-3-hydroxypropyl]amino}-9-oxo-17-{[2-(trimethylsilyl)ethoxy]methyl}-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate 
• 1422510-23-3 (R)-1-(3-chlorophenyl)-3-iodopropan-1-ol 
• 1422510-24-4 1-(3-chlorophenyl)-3-iodopropan-1-one 
• 1422509-95-2 1-(3-chlorophenyl)-3-iodopropan-1-ol 
• 929565-63-9 C₉H₁₀Cl₂O 

Relevant academic research and scientific papers

CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.