898805-59-9Relevant academic research and scientific papers
Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1
Brugel, Todd A.,Maier, Jennifer A.,Clark, Michael P.,Sabat, Mark,Golebiowski, Adam,Bookland, Roger G.,Laufersweiler, Matthew J.,Laughlin, Steven K.,VanRens, John C.,De, Biswanath,Hsieh, Lily C.,Mekel, Marlene J.,Janusz, Michael J.
, p. 3510 - 3513 (2007/10/03)
A new class of tumor necrosis factor alpha (TNF-α) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-α productio
