89882-70-2

Upstream product

• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 4136-97-4 methyl 4-aminosalicylate 
• 100-39-0 benzyl bromide 
• 107351-63-3 C₁₉H₁₈N₄O₄ 
• 107351-59-7 2-benzyloxy-4-acetamidobenzoic acid methyl ester 
• 107351-60-0 N-(3-(benzyloxy)-4-(hydroxymethyl)phenyl)acetamide 
• 65-49-6 4-Aminosalicylic acid 
• 89882-69-9 N-(3-(benzyloxy)-4-formylphenyl)acetamide 

Downstream Products

• 107351-64-4 4-benzyloxy-6-aminoindole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Substituted benzene and heterocyclic compound and its preparation method and application

The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.

Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives

Based on the chemical structure of Pyrroloquinoline quinone (PQQ), a novel class of indole-2-carboxylate derivatives was designed, synthesized and assayed for antiproliferative activity in cancer cells in vitro. The biological results showed that some der

SYNTHESIS OF THE BACTERIAL COENZYME METHOXATIN

A short total synthesis of the bacterial coenzyme methoxatin (1) (4,5-dihydro-4,5-dioxo-1H-pyrroloquinoline-2,7,9-tricarboxylic acid) is described.The route involves the two step conversion of 4-acetamido-2-benzyloxybenzaldehyde (5b) into methyl 6-acetamido-4-benzyloxyindole-2-carboxylate (7b) (74percent), followed by regioselective annulation of the third ring (55percent), and debenzylation and oxidation with benzoyl t-butyl nitroxide to give the tricyclic quinone triester (13) (methoxatin triester) (83percent).

Synthesis of the Bacterial Coenzyme Methoxatin

A short synthesis of the bacterial coenzyme methoxatin, based on the thermolysis of the azide (3) to give the indole (4) and the regioselective formation of the pyrroloquinoline (5), is described.