89894-49-5 Usage
Uses
Used in Pharmaceutical Industry:
(3,5-dichloro-4-hydroxyphenyl)acetic acid is utilized as a non-steroidal anti-inflammatory drug (NSAID) for its ability to inhibit prostaglandin production, thereby reducing pain and inflammation. This makes it a valuable component in the development of medications aimed at treating conditions characterized by these symptoms.
Used in Cancer Therapy Research:
In the field of oncology, (3,5-dichloro-4-hydroxyphenyl)acetic acid is being explored as a potential therapeutic agent due to its capacity to induce apoptosis in cancer cells. This property suggests that it could be a candidate for the development of new cancer treatments, particularly for cancers where existing therapies are limited or ineffective.
Used in Antimicrobial Applications:
(3,5-dichloro-4-hydroxyphenyl)acetic acid has shown antimicrobial properties, indicating its potential use in the development of new antimicrobial agents. This could be particularly beneficial in addressing the growing issue of antibiotic resistance and the need for novel antimicrobial compounds.
Used in Antioxidant Formulations:
Given its antioxidant properties, (3,5-dichloro-4-hydroxyphenyl)acetic acid can be incorporated into formulations for use in various industries, such as cosmetics, food and beverage, and healthcare, to provide protection against oxidative stress and promote overall health and wellness.
Check Digit Verification of cas no
The CAS Registry Mumber 89894-49-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,8,9 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 89894-49:
(7*8)+(6*9)+(5*8)+(4*9)+(3*4)+(2*4)+(1*9)=215
215 % 10 = 5
So 89894-49-5 is a valid CAS Registry Number.
89894-49-5Relevant academic research and scientific papers
Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin
Kang, Dong Wook,Kim, Yong Soo,Lim, Kwang Su,Kim, Myeong Seop,Pearce, Larry V.,Pavlyukovets, Vladimir A.,Tao, Andy K.,Lang-Kuhs, Krystle A.,Blumberg, Peter M.,Lee, Jeewoo
experimental part, p. 8092 - 8105 (2011/01/13)
As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3- methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with Ki (ant) = 2.77 and 2.19 nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.
