89898-51-1

Usage

Uses

Used in Flavoring Industry:
Tetrahydro-4-oxo-3-furoic acid ethyl ester is used as a flavoring agent for its distinctive sweet, fruity scent, enhancing the taste and aroma of various food products.
Used in Perfumery Industry:
Tetrahydro-4-oxo-3-furoic acid ethyl ester serves as a key ingredient in perfumes, leveraging its pleasant odor to contribute to the overall fragrance profile of different scented products.
Used in Pharmaceutical Production:
Tetrahydro-4-oxo-3-furoic acid ethyl ester is utilized in the manufacturing process of pharmaceuticals, potentially due to its chemical properties that can be beneficial in drug formulation and synthesis.
Used as a Precursor in Organic Synthesis:
In the chemical industry, this ester acts as a precursor for the synthesis of other organic compounds, highlighting its versatility and importance in creating a range of chemical products.

Upstream product

• 623-50-7 ethyl 2-hydroxyacetate 
• 140-88-5 ethyl acrylate 

Downstream Products

• 848398-40-3 5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 848398-41-4 2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine 
• 1542710-75-7 N-benzyl-2-(2-methyl-2H-indol-1(7aH)-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine 
• 1542711-45-4 C₁₃H₁₂ClN₃O 
• 22929-52-8 tetrahydrofuran-3-one 

Relevant academic research and scientific papers

Synthesis method of tetrahydrofuran-3-ketone

The invention discloses a synthesis method of tetrahydrofuran-3-ketone. The method comprises the following steps of: under an alkaline condition, mixing glycolate (I) and acrylate (II) in a solvent, and carrying out condensation cyclization reaction to obtain 4-formic ester-tetrahydrofuran-3-ketone (III); then, under an acidic condition, performing reflux decarboxylation reaction on the 4-formic ester-tetrahydrofuran-3-ketone (III) so as to obtain thetetrahydrofuran-3-ketone (IV) . According to the synthesis method of the tetrahydrofuran-3-ketone, the yield is greater than 82%; and the method has the advantages of mild and easily-controlled conditions, mild reaction, simple and safe operation and environmental friendliness.

FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.

OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).

HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA

This invention relates to compounds of the formula 1 wherein X, Y, Z, A, R', R2, R3, R4, R9, W' and W2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other diso