89938-78-3

Usage

Chemical Properties

Tan powder

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 910230-30-7 2-amino-5-chlorobenzoyl chloride 
• 635-21-2 5-chloroanthranilic acid 
• 89979-12-4 5-chloro-2-(methylsulfonamido)benzoic acid 

Downstream Products

• 902154-50-1 N-(4-chloro-2-formylphenyl)methanesulfonamide 
• 1602923-06-7 N-(5-(5-chloro-2-(methylsulfonamido)phenyl)-5-hydroxypent-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide 
• 1602922-58-6 8-chloro-4a-(4-methoxyphenyl)-5-(methylsulfonyl)-2-tosyl-1,2,3,4,4a,5-hexahydrobenzo[b][1,6]naphthyridine 
• 902154-60-3 N-(4-chloro-2-hydroxymethyl-phenyl)-methanesulfonamide 
• 1353623-88-7 (S)-N-(4-chloro-2-(2-(5-(3-fluoroazetidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide trifluoroacetic acid salt 
• 1353628-82-6 C₂₈H₃₆ClN₇O₅S 

Relevant academic research and scientific papers

SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway

Disruption of cyclic adenosine monophosphate response element binding protein (CREB) provides a potential new strategy to address acute leukemia, a disease associated with poor prognosis, and for which conventional treatment options often carry a significant risk of morbidity and mortality. We describe the structure-activity relationships (SAR) for a series of XX-650-23 derived from naphthol AS-E phosphate that disrupts binding and activation of CREB by the CREB-binding protein (CBP). Through the development of this series, we identified several salicylamides that are potent inhibitors of acute leukemia cell viability through inhibition of CREB-CBP interaction. Among them, a biphenyl salicylamide, compound 71, was identified as a potent inhibitor of CREB-CBP interaction with improved physicochemical properties relative to previously described derivatives of naphthol AS-E phosphate.

Construction of divergent fused heterocycles via an acid-promoted intramolecular ipso-Friedel-Crafts alkylation of phenol derivatives

Two different cascade cyclization processes were developed using aryl group-substituted propargyl alcohol derivatives with a p-hydroxybenzylamine unit as common substrates. Using TFA as an acid promoter, an intramolecular ipso-Friedel-Crafts alkylation of

COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections