89940-71-6

Basic information

• Product Name: Piperazine, 2,3,5-trimethyl- (6CI,7CI,9CI)
• Synonyms: Piperazine, 2,3,5-trimethyl- (6CI,7CI,9CI)
• CAS NO: 89940-71-6
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.21534
• Product Categories: PIPERAZINE
• Mol File: 89940-71-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 2,3,5-trimethyl- (6CI,7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2,3,5-trimethyl- (6CI,7CI,9CI)(89940-71-6)
• EPA Substance Registry System: Piperazine, 2,3,5-trimethyl- (6CI,7CI,9CI)(89940-71-6)

Safety Data

• Hazardous Substances Data: 89940-71-6(Hazardous Substances Data)

Upstream product

• 78-90-0 1,2-diaminopropan 
• 431-03-8 dimethylglyoxal 
• 57-55-6 propylene glycol 
• 14667-55-1 2,3,5-trimethylpyrazine 

Downstream Products

• 14667-55-1 2,3,5-trimethylpyrazine 

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

Reduction of Heterocycles with Nickel-Aluminum Alloy

Pyrazines, pyridazines, isoxazoles, oxazole, 4-methylpyrimidine, and indole are reduced by nickel-aluminum alloy in potassium hydroxide solution.The reaction is simple to carry out and does not require special apparatus or hydrogen atmospheres.The products were the fully hydrogenated species although benzene rings were not attacked. 4-Methylpyrimidine gave 1,3-diaminobutane and oxazole gave 2-(methylamino)ethanol.It was found that the reaction frequently exhibited an induction period.