899429-25-5Relevant academic research and scientific papers
Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis
Badir, Shorouk O.,Dong, Weizhe,Molander, Gary A.,Zhang, Xuange
, p. 4250 - 4255 (2021)
A general aminoalkylation of aryl halides was developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals are generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides are also amenable.
Asymmetric [1,2] Stevens rearrangement of (S)-N-benzylic proline-derived ammonium salts under biphasic conditions
Tayama, Eiji,Nanbara, Shintaro,Nakai, Takeshi
, p. 478 - 479 (2007/10/03)
The Stevens rearrangement of (S)-N-benzylic proline-derived ammonium salt with cesium hydroxide in 1,2-dichloroethane is shown to proceed with a high degree of the N-to-C chirality transmission to afford the α-substituted proline derivatives in high enantio-purities. Copyright
