89946-09-8Relevant academic research and scientific papers
Anti-inflammatory activities of selected synthetic homoisoflavanones
Shaikh, Mahidansha M.,Kruger, Hendrik G.,Bodenstein, Johannes,Smith, Peter,Du Toit, Karen
, p. 1473 - 1482 (2012/09/22)
Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. Invitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide (MTT) assay. Compound 4a exhibited a tendency to inhibit oedema in a dose-dependent manner after 3 and 6 h of treatment. Compounds 4b-4d also inhibited oedema, although a clear dose-response relationship was not observed. Compounds 4a-4c were found to be less cytotoxic than compound 4d. Compound 4b was the least cytotoxic. Compounds 4a-4d exhibited anti-inflammatory activity and varying levels of cytotoxicity.
Structure of a New Homoisoflavanone from Caesalpinia pulcherrima
Parmar, V.S.,Singh, S.,Jacobsen, J.P.,Boll, P.M.
, p. 267 - 270 (2007/10/02)
The structure of 8-methoxybonducellin isolated from the stem part of Caesalpinia pulcherrima has been shown to be 2, by unambigous synthesis of both 7,8-dimethoxy-3-(4'-hydroxybenzylidene)-chroman-4-one (1) and 7-hydroxy-8-methoxy-3-(4'-methoxybenzylidene-)-chroman-4-one (2).
