64139-40-8Relevant academic research and scientific papers
The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae (sensu APGII)
Schwikkard, Sianne,Whitmore, Hannah,Sishtla, Kamakshi,Sulaiman, Rania S.,Shetty, Trupti,Basavarajappa, Halesha D.,Waller, Catherine,Alqahtani, Alaa,Frankemoelle, Lennart,Chapman, Andy,Crouch, Neil,Wetschnig, Wolfgang,Knirsch, Walter,Andriantiana, Jacky,Mas-Claret, Eduard,Langat, Moses K.,Mulholland, Dulcie,Corson, Timothy W.
, p. 1227 - 1239 (2019/04/25)
Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangiogenic
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction
Mahalingam, Poornachandran,Takrouri, Khuloud,Chen, Ting,Sahoo, Rupam,Papadopoulos, Evangelos,Chen, Limo,Wagner, Gerhard,Aktas, Bertal H.,Halperin, Jose A.,Chorev, Michael
, p. 5094 - 5111 (2014/07/08)
The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro ch
Anti-inflammatory activities of selected synthetic homoisoflavanones
Shaikh, Mahidansha M.,Kruger, Hendrik G.,Bodenstein, Johannes,Smith, Peter,Du Toit, Karen
experimental part, p. 1473 - 1482 (2012/09/22)
Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. Invitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide (MTT) assay. Compound 4a exhibited a tendency to inhibit oedema in a dose-dependent manner after 3 and 6 h of treatment. Compounds 4b-4d also inhibited oedema, although a clear dose-response relationship was not observed. Compounds 4a-4c were found to be less cytotoxic than compound 4d. Compound 4b was the least cytotoxic. Compounds 4a-4d exhibited anti-inflammatory activity and varying levels of cytotoxicity.
