89960-07-6Relevant academic research and scientific papers
Using Methanol as a Formaldehyde Surrogate for Sustainable Synthesis of N-Heterocycles via Manganese-Catalyzed Dehydrogenative Cyclization
Li, Yibiao,Liu, Qiang,Shao, Zhihui,Yuan, Shanshan
, (2022/02/23)
The development of an efficient and sustainable synthetic route for formaldehyde production from renewable feedstock, especially in combination with a subsequent transformation to straightforwardly construct valuable chemicals, is highly desirable. Herein, we report a novel manganese-catalyzed dehydrogenative cyclization of methanol as a formaldehyde surrogate with a variety of dinucleophiles for facile synthesis of N-heterocycles. The in situ generated formaldehyde via catalytic methanol dehydrogenation can be selectively trapped by diverse dinucleophiles to avoid several possible side reactions. The utility of this transformation is further highlighted by its successful application to the synthesis of 13C-labeled N-heterocycles using 13CH3OH as a readily accessible 13C-isotope reagent.
Deprotection of the indole (Nind)-formyl (for) group on tryptophan employing a new reagent, N,N′-dimethylethylendiamine (DMEDA) in an aqueous solution
Odagami, Takenao,Tsuda, Yuko,Kogami, Yuji,Kouji, Hiroyuki,Okada, Yoshio
experimental part, p. 211 - 213 (2009/10/15)
The deprotection of the indole (N ind)-formyl (For) group on Trp was achieved in a 95% yield using N,N′-di- methylethylendiamine (DMEDA) (1.5, 2.0, 3.0 eq) in water at room temperature. A new reagent was successfully applied to the deprotection
