89965-52-6

Upstream product

• 81254-79-7 (2R,3S)-2-(2-(benzyloxy)benzamido)-3-hydroxybutanoic acid 
• 119-36-8 methyl salicylate 
• 82679-55-8 D-threonine methyl ester 
• 69-72-7 salicylic acid 
• 81254-81-1 3-(2-benzyloxybenzoyl)-1,3-thiazolidine-2-thione 
• 55142-16-0 methyl 2-(benzyloxy)benzoate 
• 14389-86-7 2-benzyloxybenzoic acid 
• 81254-80-0 (2R,3S)-methyl 2-(2-(benzyloxy)benzamido)-3-hydroxybutanoate 

Downstream Products

• 89965-53-7 (4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole 
• 89965-55-9 (4S,5R)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 74149-70-5 parabactin 
• 89965-57-1 (4S,5R)-N-<3-(benzyloxycarbonylamino)propyl>-N-<4-(benzyloxycarbonylamino)butyl>-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxamide 
• 89965-54-8 (4S,5R)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid 

Relevant academic research and scientific papers

Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products

Serotonin (5-HT) receptors are important in health and disease, but the existence of 14 subtypes necessitates selective ligands. Previously, the pulicatins were identified as ligands that specifically bound to the subtype 5-HT2B in the 500 nM to 10 μM range and that exhibited in vitro effects on cultured mouse neurons. Here, we examined the structure-activity relationship of 30 synthetic and natural pulicatin derivatives using binding, receptor functionality, and in vivo assays. The results reveal the 2-arylthiazoline scaffold as a tunable serotonin receptor-targeting pharmacophore. Tests in mice show potential antiseizure and antinociceptive activities at high doses without motor impairment.

Total Synthesis of Parabactin, a Spermidine Siderophore

The stereoselective total synthesis of parabactin (1) has been efficiently carried out using substituted 1,3-thiazolidine-2-thione as a leaving group.