89967-01-1

Basic information

• Product Name: Pyrimidine, 4-(chloromethyl)-2-methyl- (9CI)
• Synonyms: Pyrimidine, 4-(chloromethyl)-2-methyl- (9CI);PyriMidine, 4-(chloroMethyl)-2-Methyl-;4-(Chloromethyl)-2-methylpyrimidine
• CAS NO: 89967-01-1
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.58618
• Product Categories: PYRIMIDINE
• Mol File: 89967-01-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyrimidine, 4-(chloromethyl)-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-(chloromethyl)-2-methyl- (9CI)(89967-01-1)
• EPA Substance Registry System: Pyrimidine, 4-(chloromethyl)-2-methyl- (9CI)(89967-01-1)

Safety Data

• Hazardous Substances Data: 89967-01-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 4-(chloromethyl)-2-methyl(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, Pyrimidine, 4-(chloromethyl)-2-methyl(9CI) is used as a building block for the creation of new agrochemicals. Its properties contribute to the development of effective pesticides and other agricultural products.
Used in Organic Chemistry:
Pyrimidine, 4-(chloromethyl)-2-methyl(9CI) is utilized in organic chemistry for its reactivity and versatility. It serves as a valuable component in the synthesis of complex organic molecules and contributes to the advancement of chemical research.
Used in Material Science:
In the field of material science, Pyrimidine, 4-(chloromethyl)-2-methyl(9CI) may have applications in the development of new materials with unique properties. Its incorporation into various compounds can lead to the creation of innovative materials with potential uses in various industries.
It is important to handle Pyrimidine, 4-(chloromethyl)-2-methyl(9CI) with caution and adhere to proper safety protocols when working with it, as with any chemical.

Upstream product

• 76240-14-7 ethyl 2-methylpyrimidine-4-carboxylate 
• 14331-54-5 2,4-dimethylpyrimidine 
• 33342-84-6 2,6-dimethylpyrimidine 1-oxide 

Downstream Products

• 89966-96-1 4-methoxymethyl-2-methylpyrimidine 
• 89966-95-0 2-methoxymethyl-4-methylpyrimidine 

Relevant articles and documents

Reaction of β-alkoxyvinyl α-ketoesters with acyclic NCN binucleophiles – Scalable approach to novel functionalized pyrimidines

Two protocols for synthesis of series of low-molecular-weight di- and tri-substituted pyrimidines bearing a functional group at the 4th position, which rely on a base-mediated condensation of amidines or guanidines with β-alkoxyvinyl α-keto esters, have been developed. This approach allowed for multigram preparation of novel pyrimidine-4-carboxylates in 21–90% yield. The synthetic utility of these compounds was demonstrated by some standard functional group transformations providing promising building blocks for organic synthesis and drug discovery.

Studies on Pyrimidine Derivatives. XXXII. Reaction of 4-Substituted 2,6-Dimethylpyrimidine 1-Oxides with Phosphoryl Chloride

The reaction of 2,6-dimethyl-4-phenylpyrimidine 1-oxide with phosphoryl chloride gave 4-chloromethyl-2-methyl-6-phenylpyrimidine exclusively.In contrast, 2,6-dimethyl-4-methoxy-pyrimidine 1-oxide and 2,6-dimethyl-4-dimethylaminopyrimidine 1-oxide reacted with the same reagent to give the corresponding 2-chloromethylpyrimidines predominantly.Keywords - pyrimidine N-oxide; chloromethylpyrimidine; phosphoryl chloride; siteselective reaction; substituent effect