89970-61-6Relevant academic research and scientific papers
Efficient and selective N-alkylation of carbamates in the presence of Cs2CO3 and TBAI
Salvatore, Ralph N.,Shin, Seung Il,Flanders, Vincent L.,Jung, Kyung Woon
, p. 1799 - 1801 (2001)
Mild and selective N-alkylation of carbamates was carried out in the presence of cesium carbonate, tetrabutylammonium iodide (TBAI), and a halide. This protocol was highly selective and efficient, offering aliphatic and aromatic N-alkyl carbamates exclusively in high yields.
Polymer- and Carbon Nanotube-Supported Heterogeneous Catalysts for the Synthesis of Carbamates from Halides, Amines, and CO2
Krawczyk, Tomasz,Jasiak, Katarzyna,Kokolus, Aneta,Baj, Stefan
, p. 1163 - 1168 (2016/07/06)
Abstract: A series of tetraalkylammonium catalysts immobilized on polystyrene or carbon nanotubes were investigated in a reaction between alkyl halides, amines, and CO2. The yield of carbamates was up to 85?% at 100?°C and 1?MPa of CO2 after 3?h (first stage 25?°C, 1 h) in the presence of Cs2CO3 and DMF as a solvent. The best results were achieved in the case of large ammonium substituents (C4 and C6) in the catalyst, benzyl amine, and benzyl chloride as reagents. The catalysts retained their activity after at least five cycles when carefully dried between cycles. Both polymer and carbon nanotube supports were equally effective, but the latter were less prone to deactivation. Graphical Abstract: [Figure not available: see fulltext.]
An efficient and chemoselective Cbz-protection of amines using silica-sulfuric acid at room temperature
Gawande, Manoj B.,Polshettiwar, Vivek,Varma, Rajender S.,Jayaram, Radha V.
, p. 8170 - 8173 (2008/03/13)
A simple, facile, and chemoselective N-benzyloxycarbonylation of amines using silica-sulfuric acid that proceeds under solvent-free conditions at room temperature has been achieved. These reactions are applicable to a wide variety of primary (aliphatic and cyclic) secondary amines, amino alcohols, and heterocyclic amines.
THE REACTION OF N,N-DIBENZYLCARBAMOYL CHLORIDE WITH N-NITROSOHYDROXYLAMINE
Nakajima, Masayuki,Anselme, Jean-Pierre
, p. 139 - 140 (2007/10/02)
The action of N,N-dibenzylcarbamoyl chloride (2) on the sodium salt of N-nitrosohydroxylamines (1) in dry acetonitrile at reflux leads to products whose formation may be rationalized in terms of carbamoylation at either oxygen of the bidentate N-nitrosohydroxylamines.
