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Usage

Uses

Used in the Production of Thermosetting Resins:
Ethylene bis(cyanoacetate) is used as a crosslinking agent for the creation of thermosetting resins. Its ability to form robust bonds between polymer chains enhances the strength and durability of the final product, making it suitable for a variety of applications.
Used in the Production of Adhesives:
In the adhesives industry, Ethylene bis(cyanoacetate) is utilized as a crosslinking agent to improve the adhesive's bonding capabilities. The strong bonds it forms ensure that the adhesive maintains its effectiveness over time, even under harsh conditions.
Used in the Production of Coatings:
Ethylene bis(cyanoacetate) is employed as a crosslinking agent in the formulation of coatings. Its contribution to the formation of a stable and robust polymer network results in coatings with enhanced resistance to wear, chemicals, and environmental factors.
However, it is important to note that Ethylene bis(cyanoacetate) presents health and environmental hazards. It is toxic if ingested and can cause skin and eye irritation upon contact. Therefore, proper handling and disposal procedures are essential when working with this chemical to mitigate potential risks.

Upstream product

• 107-21-1 ethylene glycol 
• 372-09-8 cyanoacetic acid 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 35234-87-8 dimethyl 2,3-dicyanofumarate 

Relevant academic research and scientific papers

Room temperature dynamic polymers based on Diels-Alder chemistry

Dynamers based on reversible Diels-Alder chemistry have been obtained and shown to undergo dynamic exchange at room temperature. Their study in solution by small-angle neutron scattering indicated the formation of long and highly flexible chains. Polydispersed molecules gave Tg values below room temperature, permitting the generation of a dynamic elastomer upon introduction of a dynamic cross-linking agent. The use of a system with a low equilibrium constant gives access to materials with interesting self-healing properties.

Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins

Dynamin I is a GTPase enzyme required for endocytosis and is an excellent target for the design of potential endocytosis inhibitors. Screening of a library of tyrphostins, in our laboratory, against the GTPase activity of dynamin I gave rise to a ìèpotent lead, 2-cyano-3-(3,4- dihydroxyphenyl)thioacrylamide (1, IC50 70 μM). Our initial investigations suggested that only the dimeric form of 1 displayed dynamin I GTPase inhibitory activity. Subsequent synthetic iterations were based on dimeric analogues and afforded a number of small molecules, low μM potent, inhibitors of dynamin I GTPase, in particular, symmetrical analogues with a minimum of two free phenolic -OHs: catechol-acrylamide (9) (IC50 = 5.1 ± 0.6 μM), its 3,4,5-trihydroxy congener (10) (IC50 = 1.7 ± 0.2 μM), and the corresponding 3-methyl ether (11) (IC 50 = 9 ± 3 μM). Increasing the length of the central alkyl spacer from ethyl to propyl (22-24) afforded essentially identical activity with IC50's of 1.7 ± 0.2, 1.7 ± 0.2, and 5 ± 1 μM, respectively. No decrease in activity was noted until the introduction of a hexyl spacer. Our studies highlight the requirement for two free amido NHs with neither the mono-N-methyl (86) nor the bis-N-methyl (87) analogues inhibiting dynamin I GTPase. A similar effect was noted for the removal of the nitrile moieties. However, modest potency was observed with the corresponding ester analogues of 9-11: ethyl ester (90), propyl ester (91), and butyl ester (92), with IC50's of 42 ± 3, 38 ± 2, and 61 ± 2 μM, respectively. Our studies reveal the most potent and promising dynamin I GTPase inhibitor in this series as (22), which is also known as BisT.