89980-83-6

Usage

Structure

A 4-bromo-2-nitrophenyl group attached to an amino group, which is further attached to a two-carbon ethanol chain

Derivative

Of 4-bromo-2-nitroaniline

Applications

Organic synthesis, pharmaceutical research (as a building block for the synthesis of various compounds), production of dyes, pigments, and other fine chemicals

Utility

The presence of a nitro and amino group in the structure makes it useful in a wide range of applications in chemical and pharmaceutical industries

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 141-43-5 ethanolamine 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 

Downstream Products

• 130131-37-2 Methanesulfonic acid 2-(4-bromo-2-nitro-phenylamino)-ethyl ester 
• 130131-32-7 (4-Bromo-2-nitro-phenyl)-(2-thiocyanato-ethyl)-amine 
• 130131-20-3 5-Bromo-2-(2-imino-thiazolidin-3-yl)-phenylamine; compound with ethanesulfonic acid 
• 90002-50-9 2-(2-amino-4-bromophenylamino)ethanol 
• 1382805-19-7 tert-Butyl 8-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-3,4-dihydropyrazino[1,2-a]benzimidazole-2(1H)-carboxylate 
• 1382805-14-2 tert-Butyl 2-(5-bromo-2-(2-hydroxyethylamino)phenylamino)-2-oxoethylcarbamate 
• 1272321-55-7 2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid 
• 1272321-50-2 (S)-tert-butyl 2-(2-(5-bromo-2-(2-hydroxyethylamino)phenylamino)-2-oxoethyl)pyrrolidine-1-carboxylate 
• 1272320-71-4 (S)-4-(2,3,5,6,13,13a-hexahydro-1H-benzo[4,5]imidazo[1,2-d]pyrrolo[2,1-g][1,4]diazepin-10-yl)benzonitrile 
• 1272321-53-5 C₂₁H₂₄BrN₃O₃S 
• 1272321-52-4 ⁽⁵⁾-tert-butyl 2-((5-bromo-1-(2-(tosyloxy)ethyl)-1H-benzo[d]imidazol-2-yl)methyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.