899822-99-2

Usage

Uses

Used in Organic Synthesis:
3-(hydroxymethyl)-3-nitro-1-(4-octylphenyl)-Ben is used as a key intermediate in organic synthesis for the production of various complex organic molecules. Its unique functional groups allow for versatile chemical reactions, facilitating the synthesis of a wide range of compounds with potential applications in pharmaceuticals, materials science, and other fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(hydroxymethyl)-3-nitro-1-(4-octylphenyl)-Ben is used as a building block for the development of new drugs. Its molecular structure can be modified to create novel drug candidates with potential therapeutic effects. 3-（hydroxymethyl）-3-nitro-1-(4-octylphenyl)-Ben's reactivity and stability make it suitable for the synthesis of pharmaceutical agents that can target specific biological pathways or receptors.
Used in Materials Science:
3-(hydroxymethyl)-3-nitro-1-(4-octylphenyl)-Ben is used as a component in the development of advanced materials with unique properties. Its incorporation into polymers, coatings, or other materials can enhance their performance, such as improving their mechanical strength, thermal stability, or chemical resistance. 3-（hydroxymethyl）-3-nitro-1-(4-octylphenyl)-Ben's versatility in chemical reactions allows for the creation of materials with tailored properties for specific applications.
Further research and testing are necessary to fully explore and harness the potential of 3-(hydroxymethyl)-3-nitro-1-(4-octylphenyl)-Ben in commercial and industrial applications. Its unique molecular structure and properties offer promising opportunities for innovation and advancement in various fields.

Upstream product

• 928165-59-7 3-chloro-1-(4-octylphenyl)propan-1-one 
• 2189-60-8 Octylbenzene 
• 1674-37-9 n-octanophenone 
• 1373549-72-4 3-nitro-1-(4-octylphenyl)propyl acetate 
• 899822-98-1 3-nitro-1-(4-octylphenyl)propan-1-ol 
• 899822-97-0 3-nitro-1-(4-octylphenyl)propan-1-one 
• 50-00-0 formaldehyd 

Downstream Products

• 162359-55-9 fingolimod 
• 1369968-69-3 (3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol 
• 374077-88-0 2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol 

Relevant academic research and scientific papers

An alternative efficient approach for the synthesis of Fingolimod hydrochloride

An efficient process for the synthesis of API Fingolimod Hydrochloride is presented. This proposed synthesis involves simple commercially available octanophenone as a starting material. The route is effective involving seven steps to achieve the target, thus reducing the cycle time, and is cost efficient by 50%. It is an immune modulating drug for the treatment of heart failure and arrhythmias.

PROCESS FOR MAKING FINGOLIMOD

The invention relates to a process of making fingolimod of formula (1), or an acid addition salt thereof comprising a step of reacting the compound of formula (11) and/or a compound of formula (14) or an acid addition salt thereof, in a solvent with hydrogen in a presence of a hydrogenation catalyst, preferably palladium catalyst, and optionally converting fingolimod of formula (1) into an acidaddition salt, to compounds of formula (11) and (14) and their use in making fingolimod.

PROCESS FOR MAKING FINGOLIMOD

The invention relates to a process of making fingolimod of formula (1), or an acid addition salt thereof comprising a step of reacting the compound of formula (11) and/or a compound of formula (14) or an acid addition salt thereof, in a solvent with hydrogen in a presence of a hydrogenation catalyst, preferably palladium catalyst, and optionally converting fingolimod of formula (1) into an acid addition salt, to compounds of formula (11) and (14), processes of making them and to their use in making fingolimod.

PROCESS FOR MAKING FINGOLIMOD

The invention relates to a process of making fingolimod of formula (1), or an acid addition salt thereof comprising a step of reacting the compound of formula (11) and/or a compound of formula (14) or an acid addition salt thereof, in a solvent with hydrogen in a presence of a hydrogenation catalyst, preferably palladium catalyst, and optionally converting fingolimod of formula (1) into an acid addition salt, to compounds of formula (11) and (14), processes of making them and to their use in making fingolimod.

INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF FINGOLIMOD

The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes.