899832-98-5Relevant academic research and scientific papers
Novel 4(3H)-quinazolinone analogs: Synthesis and anticonvulsant activity
El-Azab, Adel S.,Abdel-Hamide, Sami G.,Sayed-Ahmed, Mohamed M.,Hassan, Ghada S.,El-Hadiyah, Tariq M.,Al-Shabanah, Othman A.,Al-Deeb, Omar A.,El-Subbagh, Hussein I.
, p. 2815 - 2827 (2013/07/26)
A new series of quinazoline analogs was designed, synthesized, and evaluated for their anticonvulsant activity. Compounds 6, 12, 21, 36, 37, and 38 showed 70-100 % protection against PTZ-induced seizures acting as GABA A receptor agonists. Compound N-(3,4,5,6-tetrachloro-phthalimido)-2- [(3-phenyl-4-oxo-6-methyl-3H-quinazolin-2-yl)-thio]acetamide (12) representing the moderate active compounds and 2-[6-iodo-4-oxo-2-(thiophen-2-yl)-quinazolin- 3(4H)-yl]-isoindoline-1,3-dione (38) representing the remarkably active compounds in this stud, showed ED50 values of 457 and 251 mg/kg; TD50 values of 562 and 447 mg/kg; PI values of 1.22 and 1.78, LD 50 values of 1,288 and 1,380 mg/kg, and TI values of 2.82 and 5.50, respectively. Compound 38 proved to be almost twofold more active than the standard drug sodium valproate.
Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs
Al-Obaid, Abdulrahman M.,Abdel-Hamide, Sami G.,El-Kashef, Hassan A.,Abdel-Aziz, Alaa A.-M.,El-Azab, Adel S.,Al-Khamees, Hamad A.,El-Subbagh, Hussein I.
experimental part, p. 2379 - 2391 (2009/11/30)
The synthesis of some new 2-thieno-4(3H)-quinazolinone derivatives and their biological evaluation as antitumor agents using the National Cancer Institute (NCI) disease oriented antitumor screen protocol are investigated. Compounds 2-(2-thienylcarbonylami
