89987-96-2

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 79528-83-9 (3-thiocyanatopropyl)benzene 
• 3012-37-1 benzyl thiocyanate 
• 24734-68-7 3-Phenylpropane-1-thiol 
• 5799-67-7 dimethyl(methylthio)sulfonium tetrafluoroborate 
• 114764-11-3 3-phenylpropyl 2-(trimethylsilyl)ethyl sulfide 
• 637-59-2 1-Bromo-3-phenylpropane 

Downstream Products

• 24734-68-7 3-Phenylpropane-1-thiol 
• 89987-01-9 Tetraisopropyl (3-phenyl-propylthio)-methylene-diphosphonate 
• 22776-35-8 2,3-dihydro-4H-1-benzothiopyran 1,1-dioxide 
• 2054-35-5 thiochromane 
• 90220-25-0 3-phenyl-1-propane-sulfonamide 
• 63014-04-0 3-Phenyl-propane-1-sulfonyl chloride 

Relevant academic research and scientific papers

Cu-mediated: vs. Cu-free selective borylation of aryl alkyl sulfones

A Cu-catalysed borylation of aryl alkyl sulfones was developed for the high yield synthesis of versatile arylboronic esters using a readily prepared NHC-Cu catalyst. In addition, the selective cleavage of either alkyl(C)-sulfonyl or aryl(C)-sulfonyl bonds

Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles

A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing a MoCl5-mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide or diselenide precursors, a high atom efficiency was achieved.

A rapid, efficient and green procedure for transformation of alkyl halides/ tosylates to organochalcogens in water

A one-pot and efficient synthesis of dialkyl dichalcogenides (S, Se) in aqueous media under catalyst-free conditions using benzylic, allylic and primary halides with elemental sulfur and selenium has been developed. Also, this procedure was extended to preparation of trisulfides and triselenides from secondary and tertiary halides in same condition. In all cases, products can be obtained in good to excellent yield in short reactions time.

Simple and green method for synthesis of symmetrical dialkyl disulfides and trisulfides from alkyl halides in water; PMOxT as a sulfur donor

An environmentally new, mild and efficient method has been developed for the synthesis of dialkyl disulfides and dialkyl trisulfides in aqueous conditions by a reaction between alkyl halides (and tosylate) and potassium-5-methyl-1,3,4-oxadiazole-2-thiolate (PMOxT) as a sulfur transfer reagent. The advantages of this method are that it occurs under mild reaction conditions, it is base free, it uses water as the solvent and it occurs in high yields. A variety of dialkyl disulfides and dialkyl trisulfides can be obtained in good to excellent yields up to 98%.

Symmetrical disulfide synthesis via nickel-catalysis using potassium sulfide as sulfur source

Abstract: An efficient one-pot method for the synthesis of organic disulfides from aryl and alkyl halides and potassium sulfide has been described. K2S acts as an inexpensive and readily available sulfur source. A variety of symmetric diaryl and dialkyl disulfides was prepared in good to excellent yields using NiCl2·6H2O and acetylacetone as the catalytic system. Graphical abstract: [Figure not available: see fulltext.]

An efficient domino Cu-mediated access to organic disulfides from aryl/alkyl halides: Sodium thiosulfate used as a sulfurating reagent

Background: We have developed a one-pot, simple and efficient protocol for the direct synthesis of symmetrical organic disulfides in high yields via domino reaction between aryl/alkyl halides and Sodium thiosulfate as the sulfur source, in the presence of copper/imidazole and K2CO3. Methods: Owing to the importance seen in the synthesis disulfides, as is evident from the number of publications in the recent past, and our continuing interest in the synthesis of organosulfur compounds using direct synthesis and domino reaction. Herein we designed the synthesis of various disulfide using reaction of aryl/alkyl halides with sodium thiosulfate in presence CuI catalyst, K2CO3 and imidazol as ligand in solvent DMSO. The reaction of iodobenzene with sodium thiosulfate was studied under normal atmospheric conditions in order to optimize the reaction conditions in terms of temperature, amount of reagent and catalyst, and the type of ligand. Results: Effect of solvent and ligand was perceptible, The reaction proceeded not well in the absence of a ligand. The best ligand for these reaction was imidazole. The various solvents tested in this investigation. It was observed that excellent yield of the product was obtained when the reaction was carried out by using DMSO as solvent. The reaction no proceeded in the absence of a base. K2CO3 was a good choice. We examined various amount of the copper salt. It was found to be the best choice in presence 0.7 mmol from copper salt. Also it was significantly found that the reaction yield and rate increased with temperature. The reaction favoured at 130°C temperature. The 3 mmol Na2S2O3·5H2O concentration was sufficient to give maximum yield of the required product in comparison with other amounts. Diaryl/alkyl disulfides were synthesized in terms of the connecting and type position of the substituents on the aryl/alkyl groups, so that products with different substituents, both electron withdrawing and electron-donating substituent, were synthesized in the ortho, meta and para positions. The results show that iodobenzene and bromobenzene were effective for the reaction. Although it was seen that the reaction cannot progress with compound of aryl chloride. Symmetrical diheteroaryl disulfides were well synthesized from the corresponding heteroaryl iodides, bromides and chlorides. Conclusion: In summary, we have developed a new and effective method for the direct synthesis of diaryl/alkyl disulfides from various aryl/alkyl halides by domino reaction. In this work reports an effective and cheap metal catalyzed sulfur transfer reaction, which is more economic, and more environmentally friendly and more comprehensive than previous methods. As a novel sulfur source, Na2S2O3 shows notable advantage in this system. This reaction functions under mild conditions, and various functional groups are well tolerated.

A novel nickel-catalyzed domino method for the direct synthesis of symmetrical disulfides using potassium 5-methyl-1,3,4-oxadiazole-2-thiolate as a sulfurating reagent

A simple, one pot, efficient, and novel protocol has been developed for the direct synthesis of symmetrical organic disulfides using a domino reaction between an aryl/alkyl halide and potassium 5-methyl-1,3,4-oxadiazole-2-thiolate in the presence of NiCl2 as catalyst. A variety of symmetrical aryl/alkyl disulfides can be obtained in moderate to excellent yields (up to 95%).

An efficient one-pot method for the direct synthesis of organic disulfides from aryl/alkyl halides in the presence of CuCl using morpholin-4-ium morpholine-4-carbo-dithioate

A novel and expedient route is described for the one-pot synthesis of symmetric diaryl (dialkyl) disulfides derivatives via morpholin-4-ium morpholine-4-carbo-dithioate and aryl (alkyl) halides reactions in the presence of CuCl in an aqueous solvent system. Morpholin-4-ium morpholine-4-carbo-dithioate used as new solid, stable and easy handle sulfur Sourcage.

Ni-Catalyzed Cross-Coupling Reaction: The Direct Synthesis of Symmetrical Disulfanes from Aryl and Primary Alkyl Halides

A novel Ni-catalyzed cross-coupling reaction is introduced for the direct synthesis of diaryldisulfanes and dialkyldisulfanes from aryl halides and primary alkyl halides at normal atmospheric conditions, respectively. This one-pot and domino protocol utilizes only 10 mol% of NiCl2 as a catalyst and morpholin-4-ium morpholine-4-carbo-dithioate as a new, stable, solid, and odorless sulfurating reagent in the presence of ethylene glycol as a cosolvent and bidentate ligand in dimethyl formamide (DMF) at 130°C with good to excellent yields and relatively short time reaction.

An efficient, one-pot and CuCl-catalyzed route to the synthesis of symmetric organic disulfides via domino reactions of thioacetamide and aryl (alkyl) halides

In this article, a simple, general and novel method for the synthesis of diaryl (dialkyl) disulfides from aryl (alkyl) halides is described. This is a convenient approach that involves the use of commercially available and inexpensive thioacetamide as a sulfur transfer reagent in the domino process for the synthesis of symmetric organic disulfides. Copyright