89990-53-4

Upstream product

• 68387-96-2 N,N'-diisobutyrylhexahydropyridazine 
• 154972-37-9 tert-butyl tetrahydropyridazine-1(2H)-carboxylate 
• 340256-13-5 tert-butyl 2-[(tert-butyl)oxycarbonyl]perhydropyridazine-1-carboxylate 
• 110-52-1 1,4-dibromo-butane 
• 189807-28-1 tetrahydropyridazine-1,2-dicarbaldehyde 
• 289-80-5 1,2-diazine 

Downstream Products

• 682802-27-3 hexahydropyridazine-1-carbothioamide 
• 61653-63-2 N-phenylhexahydropyridazine-1-carbothioamide 
• 61653-57-4 tetrahydro-pyridazine-1-carbothioic acid (4-methoxy-phenyl)-amide 
• 682802-36-4 tetrahydro-pyridazine-1-carbothioic acid (2-methoxy-phenyl)-amide 
• 706778-81-6 N-benzyloxy-N-[(2R)-cyclopentylmethyl-3-oxo-3-(tetrahydropyridazin-1-yl)propyl]formamide 
• 939964-17-7 (R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 69386-74-9 3-amino-5,6,7,8-tetrahydro-1H-pyrazolo[1,2-a]pyridazin-1-one 
• 1160943-52-1 trans-cinnamaldehyde dimethylacetal 
• 1160943-43-0 C₁₃H₁₇N₂⁽¹⁺⁾*ClH 
• 1160943-48-5 C₁₃H₁₇N₂⁽¹⁺⁾*ClH 
• 1181082-12-1 (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-1-methyl-4,5-dihydro-1H-imidazol-4-one 
• 1181082-14-3 (5Z)-5-[(5-bromo-4-fluoro-2-hydroxyphenyl)methylidene]-2-(1,2-diazinan-1-yl)-4,5-dihydro-1,3-thiazol-4-one 

Relevant academic research and scientific papers

Preparation method of hexahydropyridazine dihydrochloride

The invention relates to a preparation method of hexahydropyridazine dihydrochloride, which comprises the following steps: reacting formic acid with hydrazine hydrate to generate N,N'-diformylhydrazine; then reacting the N,N'-diformylhydrazine with 1,4-dibromobutane under the alkaline condition to generate tetrahydropyridazine-1,2-diformaldehyde; and finally reacting the tetrahydropyridazine-1,2-diformaldehyde with hydrochloric acid to generate the hexahydropyridazine dihydrochloride. Compared with the prior art, the method provided by the invention has the advantages of easily available and cheap raw materials, mild reaction, simple operation, low requirements on reaction equipment, and easy industrialization.

HERBICIDAL BENZOXAZINONES

The present invention provides benzoxazinones of formula I wherein R1 is hydrogen or halogen; R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3/

Substituted Pyrazalones

The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such a

Development of cyclic hydrazine and hydrazide type organocatalyst-mechanistic aspects of cyclic hydrazine/hydrazide-catalyzed diels-alder reactions

Some hydrazines and hydrazides were prepared and screened for their catalytic efficiencies in Diels-Alder reactions. 1H-NMR studies and ab initio calculations revealed that catalytic efficiencies of these catalysts are greatly dependent on the release of the catalysts from the Diels-Alder adducts.

Biginelli reactions catalyzed by hydrazine type organocatalyst

Pyrazolidine dihydrochloride can be used in the acceleration of Biginelli reactions between urea, ethyl acetoacetate and various aldehydes to provide DHPMs in good to excellent yields.

PYRAZOLE DERIVATIVES

A compound represented by formula (I): (wherein Ar1 represents a phenyl group which may have 1 to 3 substituents, or a non-substituted 5- or 6-membered aromatic heterocyclic group; Ar2 represents (i) a non-substituted phenyl group, (ii) a phenyl group which has been substituted by a lower alkyl group having 1 to 3 groups or atoms selected from among a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom, or (iii) a 5- or 6-membered nitrogen-containing aromatic heterocyclic group which has been substituted by 1 to 3 groups or atoms selected from among a lower alkyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group, a cyano group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom; and X represents a group represented by formula (II): (wherein the ring structure represents a 4- to 7-membered heterocyclic group which may have, in addition to the nitrogen atom shown in formula (II), one heteroatom selected from among nitrogen, oxygen, and sulfur, and which may be substituted by 1 to 4 groups or atoms selected from among a lower alkyl group, a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, an oxo group, a lower alkanoyl group, a lower alkylsulfonyl group, and a halogen atom)), a salt thereof, a solvate of the compound or the salt, and a drug.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

Synthesis, biological evaluation and structural determination of β-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of β-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)but an-1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.

Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye

Disclose herein is a composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising at least one oxidation base chosen from diamino-N,N-dihydropyrazolones and addition salts thereof, at least one coupler, and at least one heterocyclic direct dye. Also disclosed herein is a method for dyeing keratin fibers comprising applying a composition of the present disclosure to the keratin fibers. The compositions and methods of the present disclosure may make it possible to obtain fast coloration of keratin fibers that is resistant to light and/or to washing.

NAPHTHALENE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.