90-49-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenylbutyrylurea is used as a key intermediate in the synthesis and development of new trypanosomicidal drug-like compounds for the treatment of diseases caused by Trypanosoma parasites.
Used in Drug Discovery:
2-Phenylbutyrylurea is employed as a valuable building block in the discovery of novel therapeutic agents with potential trypanosomicidal activity, contributing to the advancement of treatments for various diseases.

InChI:InChI=1/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15)

Upstream product

• 50-06-6 phenobarbital 
• 36854-57-6 2-Phenylbutyryl chloride 
• 57-13-6 urea 
• 6498-10-8 carbonyl diisocyanate 
• 90-27-7 2-Phenylbutyric acid 
• 744-80-9 Benzoylphenobarbital 
• 7732-18-5 water 
• 57-30-7 phenobartital sodium 

Downstream Products

• 93596-91-9 1-benzoyl-3-(2-phenylbutyryl)urea 

Relevant academic research and scientific papers

Reactions of Carbonyl Diisocyanate with Amides and Acids

Carbonyl diisocyanate (1) reacts with primary amides to give 1-acylated isocyanuric acids (5, 6).With secondary amides, 1 affords the rather instable oxadiazinediones 4, which for certain substituents rearrange to give triazines (5, 10).With nucleophiles, compounds 4 give oligourets, e.g. with ureas pentaurets (11, 12) were obtained.Carbonyl diisocyanate reacts with hydrogen halides to afford the crystalline urea-1,3-dicarbonyl halides 13a-c.Diverse products (16, 17, 24, 26) were obtained with carboxylic acids.In most cases oxadiazinediones (26) were isolated, which can be transformed with nucleophiles into acyl ureas 30, 31, biurets 32, and triurets 33.Acetylation of 26 leads to the reactive heterocycles 34.

HYDROLYSIS OF BARBITURIC ACID DERIVATIVES. PART V. HYDROLYSIS OF 1-BENZOYL-5-ETHYL-5-PHENYLBARBITURIC ACID

The pathways of hydrolytic degradation of 1-benzoyl-5-ethyl-5-phenylbarbituric acid have been investigated.The profiles of log k - pH of hydrolyses of 1-benzoyl-5-ethyl-5-phenylbarbituric acid and the main hydrolytic product i.e. 1-benzoyl-3-(2-phenylbutyryl)urea have been determined and discussed.