90004-05-0

Basic information

• Product Name: 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE)
• Synonyms: 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE);2-[1,3,4]Oxadiazol-2-yl-phenylamine
• CAS NO: 90004-05-0
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16068
• Mol File: 90004-05-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE)(90004-05-0)
• EPA Substance Registry System: 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE)(90004-05-0)

Safety Data

• Hazardous Substances Data: 90004-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE) is used as a key intermediate in the synthesis of Heteroaryl compounds, which are known as ZNF143 inhibitors. These inhibitors play a crucial role in modulating the activity of the ZNF143 protein, a transcription factor involved in various cellular processes. By targeting ZNF143, these Heteroaryl compounds have the potential to treat diseases associated with the dysregulation of this protein, such as cancer and other genetic disorders.
In the synthesis of Heteroaryl compounds, 2-(1,3,4-oxadiazol-2-yl)aniline(SALTDATA: FREE) serves as a building block, providing the necessary oxadiazole moiety that can be further functionalized and combined with other molecular fragments to create the desired ZNF143 inhibitors. This makes it an essential component in the development of novel therapeutic agents targeting this important protein.

Upstream product

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Relevant articles and documents

Synthesis and single crystal X-ray structure of 2-(1,3,4-oxadiazol-2-yl) aniline

Reaction of 2-aminobenzoic acid with (N-isocyanimino)triphenylphosphorane proceeds smoothly at r. t. to afford 2-(1,3,4-oxadiazol-2-yl)aniline in high yield. The structure of this compound was confirmed by IR, 1H, and 13C NMR spectro

COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a compound having a ZNF143 inhibitory activity as well as to provide a ZNF143 inhibitory agent and pharmaceutical composition containing the same. SOLUTION: Provided is a compound represented by formula (I) or a salt thereof as well as a ZNF143 inhibitory agent containing the same and a pharmaceutical composition having the same as an active ingredient. A-B-C-D (I)[A is H, a methyl group, a naphthyl group, a phenyl group or a nitrogen-containing heterocyclic ring; B is as shown below, and C is an amide bond or a heteroaromatic ring containing N and O; D is a substituted/unsubstituted phenyl group or a monocyclic heteroaromatic ring containing N or S; and C and D are both fused heterocyclic ring or the like optionally having a substituent group.]. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

Novel, fast and efficient one-pot sonochemical synthesis of 2-aryl-1,3,4-oxadiazoles

Ultrasound promoted synthesis of 2-aryl-1,3,4-oxadiazoles at ambient temperature is reported. The remarkable features of the new procedure are shorter reaction time, excellent yields, cleaner reaction profile and simple experimental and workup procedure.

The reaction of (N-isocyanimino)triphenylphosphorane with anthranilic acid derivatives: One-pot synthesis of 2-substituted 1,3,4-oxadiazoles via intramolecular aza-wittig reaction

The reaction of anthranilic acid derivatives with (N-isocyanimino) triphenylphosphorane proceeds smoothly at room temperature to afford 2-substituted 1,3,4-oxadiazoles via an intramolecular aza-Wittig reaction in excellent yields under neutral conditions.