90004-94-7

Basic information

• Product Name: ETHANONE, 1-(4-BROMO-2-NITROPHENYL)-
• Synonyms: ETHANONE, 1-(4-BROMO-2-NITROPHENYL)-;1-(4-bromo-2-nitrophenyl)ethanone;4'-Bromo-2'-nitroacetophenone;1-(4-broMo-2-nitrophenyl)ethan-1-one;1-(4-Bromo-2-nitrophenyl);Acetophenone,4'-Bromo-2'-Nitro- (7Ci
• CAS NO: 90004-94-7
• Molecular Formula: C₈H₆BrNO₃
• Molecular Weight: 244.043
• Mol File: 90004-94-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 70℃
• Boiling Point: 345.9 °C at 760 mmHg
• Flash Point: 163 °C
• Appearance: /
• Density: 1.637
• Vapor Pressure: 5.97E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHANONE, 1-(4-BROMO-2-NITROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: ETHANONE, 1-(4-BROMO-2-NITROPHENYL)-(90004-94-7)
• EPA Substance Registry System: ETHANONE, 1-(4-BROMO-2-NITROPHENYL)-(90004-94-7)

Safety Data

• Hazardous Substances Data: 90004-94-7(Hazardous Substances Data)

Usage

Uses

1-(4-Bromo-2-nitrophenyl)ethanone is a useful reactant in organic reactions.

InChI:InChI=1/C8H6BrNO3/c1-5(11)7-3-2-6(9)4-8(7)10(12)13/h2-4H,1H3

Upstream product

• 10342-66-2 4-bromo-1-ethyl-2-nitro-benzene 
• 1262802-05-0 (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime 
• 99-90-1 para-bromoacetophenone 
• 99277-72-2 diethyl 2-(4-bromo-2-nitrobenzoyl)malonate 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 1414956-67-4 7-bromocinnolin-4(1H)-one 
• 1414956-68-5 7-(4-(methylsulfonyl)phenyl)cinnolin-4(1H)-one 
• 1414956-69-6 3-iodo-7-(4-(methylsulfonyl)phenyl)cinnolin-4(1H)-one 
• 1414956-71-0 4-chloro-3-iodo-7-(4-(methylsulfonyl)phenyl)cinnoline 
• 1414956-73-2 3-iodo-N-isopropyl-7-(4-(methylsulfonyl)phenyl)cinnolin-4-amine 
• 1414955-86-4 N-isopropvl-7-(4-(methylsulfonyl)phenyl)-3-(thiazol-4-yl)cinnolin-4-amine 
• 1414956-13-0 N-isopropyl-3-methyl-7-(4-(methylsulfonyl)phenyl)cinnolin-4-amine 
• 1414956-37-8 3-ethynyl-N-isopropyl-7-(4-(methylsulfonyl)phenyl)cinnolin-4-amine 
• 1414956-47-0 3-(1H-imidazol-2-yl)-N-isopropyl-7-(4-(methylsulfonyl)phenyl)cinnolin-4-amine 

Relevant articles and documents

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Palladium-catalyzed chelation-assisted aromatic C-H nitration: Regiospecific synthesis of nitroarenes free from the effect of the orientation rules

A palladium-catalyzed chelation-assisted ortho-nitration of aryl C-H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-methyl oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed ipso-nitration of C-H bond as a key step. Mechanistic investigations support a silver-mediated radical mechanism involving Pd((II/III) and/or Pd(II/IV) catalytic cycles under oxidizing conditions.

Regiospecific synthesis of nitroarenes by palladium-catalyzed nitrogen-donor-directed aromatic C-H nitration

Nitration of N-heteroaromatics: The first example of palladium-catalyzed direct ortho-nitration of aryl C-H bonds is described. A range of azaarenes, such as 2-arylquinoxalines, pyridines, pyrazoles, and O-methyl oximes, were nitrated with excellent chemo- and regioselectivity (see scheme; DCE=1,2-dichloroethane). Preliminary mechanistic investigations support a silver-mediated radical mechanism involving palladium(II/III) and/or palladium(II/IV) catalytic cycles under oxidizing conditions. Copyright