90005-61-1

Basic information

• Product Name: 2-(pyridin-2-yl)propanoic acid
• Synonyms: 2-(pyridin-2-yl)propanoic acid
• CAS NO: 90005-61-1
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Mol File: 90005-61-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(pyridin-2-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(pyridin-2-yl)propanoic acid(90005-61-1)
• EPA Substance Registry System: 2-(pyridin-2-yl)propanoic acid(90005-61-1)

Safety Data

• Hazardous Substances Data: 90005-61-1(Hazardous Substances Data)

Usage

Structure

Contains a pyridine ring, making it an aromatic compound

Applications

Used in the pharmaceutical industry for synthesizing drugs and pharmaceutical intermediates
Potential applications in organic chemistry for synthesizing other compounds

Chemical Properties

Carboxylic acid: Can participate in various chemical reactions
Acts as an important building block for creating more complex molecules

Upstream product

• 109-06-8 α-picoline 
• 150059-62-4 tert-butyl 2-(pyridin-2-yl)acetate 
• 1419602-53-1 tert-butyl 2-(pyridin-2-yl)propanoate 

Downstream Products

• 1190615-44-1 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(pyridin-3-yl)methyl]-5-(4-{[(2R)-2-pyridin-2-ylpropanoyl]amino}benzyl)pyrrolidine-1-carboxylate 
• 1190615-45-2 tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(pyridin-3-yl)methyl]-5-(4-{[(2S)-2-pyridin-2-ylpropanoyl]amino}benzyl)pyrrolidine-1-carboxylate 
• 1419596-68-1 N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(pyridin-2-yl)propanamide 
• 1419596-72-7 N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(pyridin-2-yl)propanamide 

Relevant articles and documents

Scalable, Telescoped Hydrogenolysis-Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids

Enantiopure α-aryl propionic acids are useful building blocks for pharmaceutical research and can be accessed enzymatically using arylmalonate decarboxylases (AMDases) from the corresponding malonic acids. However, the intrinsic instability of malonic acids is a major drawback to this approach in which spontaneous decarboxylation can occur, subsequently eroding enantioselectivity and giving rise to racemic products. This was particularly evident for a panel of N-heterocyclic propionic acids that we wished to access using the approach. Herein, we describe a process to overcome the spontaneous decarboxylation problem in which hydrogenolysis of the corresponding dibenzyl malonates was performed in a biphasic toluene-basic aqueous buffer mixture and telescoped into the subsequent AMDase step. This procedure enabled compounds to be accessed in high enantioselectivities and was successfully demonstrated on 120 g with high yield (76%) and ee (98%).

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heterocyclic Aza Compounds

Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.

Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.