90008-31-4

Upstream product

• 22934-23-2 2-amino-4,6-dimethyl-3-nitropyridine 
• 22934-22-1 3-Nitro-6-amino-2,4-dimethyl-pyridin 

Relevant academic research and scientific papers

Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists

Substituted Imidazo-fused 6-membered heterocycles of structural formula: STR1 wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.

ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED PYRIDOIMIDAZOLYL RING

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. STR1

Angiotensin II antagonists incorporating a substituted thiophene or furan

There are disclosed substituted thiophene and furan derivatives of Formula I which are useful as angiotensin II antagonists. STR1

SUBSTITUTED IMIDAZO-FUSED 6-MEMBERED HETEROCYCLCES AS ANGIOTENSIN II ANTAGONISTS

Substituted Imidazo-fused 6-membered heterocycles of structural formula: STR1 wherein A, B, C, and D are independently carbon atoms or nitrogren atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.

Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle

There are disclosed compounds, containing a pyridine, pyrazine or pyrimidine functionality on the lower ring of Formula I, which are useful as angiotensin II antagonists. STR1

Microbial transformation process for antihypertensive products

Fermentation of the microorganism Streptomyces sp. MA6751 (ATCC No. 55043) in the presence of the Angiotensin II (A II) receptor antagonist yields an N2-tetrazole β-glucuronide analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

ANGIOTENSIN II ANTAGONISTS INCORPORATING AN INDOLE OR DIHYDROINDOLE

There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists. STR1

MICROBIAL TRANSFORMATION PROCESS FOR PREPARING ANTI-HYPERTENSIVE PRODUCTS

Fermentation of the microorganism Streptomyces sp. (MA6750) ATTC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist STR1 yields three analogs, each having a shikimate sugar-like moiety attached to the tetrazole, which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

Anti-hypersensitive N2-tetrazole-β-glucuronide analog

Fermentation of the microorganism Streptomyces sp. MA6751 in the presence of STR1 yields an anti-hypertensive compound of the structure STR2

Antihypertensive products, a process for their preparation and pharmaceutical compositions containing them.

Fermentation of the microorganism Actinoplanacete sp. in the presence of the Angiotensin II (A II) receptor antagonist yields a 5-hydroxymethyl and a 7-hydroxymethyl analog, both of which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.