900161-13-9

Basic information

• Product Name: (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid
• Synonyms: (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid;Naphtho[2,3-c]furan-4-carboeylic acid,7-[(ehoxycarbonyl)amino]dodecahydro-3-methyl-1-oxo-(3R、3aR、4S、4aR、7R、8aR、9aR)-;(3R,3aR,4S,4aR,7R,8aR,9aR)-7-((Ethoxycarbonyl)amino)-3-methyl-1-oxododecahydronaphtho[2,3-c]furan-4-carboxylic acid;Vorapaxar int-A;(3R,3aR,4S,4aR,7R,8aR,9aR)-7-[(Ethoxycarbonyl)amino]dodecahydro-3-methyl-1-oxonaphtho[2,3-c]furan-4-carboxylic acid;(3R,3aS,4S,4aR,8aR,9aR)-3-methyl-1,7-dioxo-N,N-diphenyl-dodecahydronaphtho[2,3-c]furan-4-carboxamide;(3R,3AR,4S,4aR,7R,8aR,9aR)-7-((Ethoxycarbonyl)amino)-3-methyl-1-oxododecahydronaphtho[2,3-c]fu;CB02738189
• CAS NO: 900161-13-9
• Molecular Formula: C16H22O6
• Molecular Weight: 310.34228
• Mol File: 900161-13-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 570.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 4.16±0.60(Predicted)
• CAS DataBase Reference: (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid(900161-13-9)
• EPA Substance Registry System: (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid(900161-13-9)

Safety Data

• Hazardous Substances Data: 900161-13-9(Hazardous Substances Data)

Usage

General Description

The chemical "(1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid" is a complex organic compound with a unique molecular structure. It contains a spiro ring system and a carboxylic acid functional group. The compound also has a methyl group and a ketone group, giving it potential biological activity. The chemical may have applications in pharmaceuticals and medicinal chemistry due to its distinct structure and potential pharmacological properties. Further research and testing are needed to fully understand its potential uses and effects.

Upstream product

• 1017854-17-9 C₂₉H₃₄N₂O₅ 
• 900161-12-8 C₂₉H₃₄N₂O₅ 
• 541-41-3 chloroformic acid ethyl ester 

Relevant articles and documents

Thrombin Receptor Antagonists Based On The Modified Tricyclic Unit Of Himbacine

Multiple stereoisomers of the heterocyclic-substituted tricyclics of the formula: or a pharmaceutically acceptable salt, solvate, or ester of said compound wherein R and the stereochemistry are illustrated in the structural formulas herein are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

SYNTHESIS OF HIMBACINE ANALOGS

The present invention relates to an improved process for preparing imbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability,