900161-12-8

Usage

Uses

Used in Pharmaceutical Industry:
Vorapaxar is used as an antiplatelet agent for the prevention of thrombotic events in patients with a history of myocardial infarction, peripheral arterial disease, or those undergoing coronary artery bypass grafting. It works by inhibiting the PAR-1 receptor, which reduces platelet aggregation and the risk of blood clot formation.
Additionally, Vorapaxar may be used in research settings to study the role of the PAR-1 receptor in platelet function and the development of new therapeutic agents targeting this receptor.

Upstream product

• 900186-76-7 C₂₆H₃₀N₂O₃ 
• 541-41-3 chloroformic acid ethyl ester 
• 900161-09-3 C₁₂H₁₇NO₄ 
• 900161-11-7 C₂₉H₃₂N₂O₅ 
• 899809-64-4 3-(5-nitro-cyclohex-1-enyl)-acrylic acid 
• 899809-61-1 (R,Z)-4-hydroxy-N,N-diphenylpent-2-ynamide 
• 900161-09-3 (R,E)-3-(5-((ethoxycarbonyl)amino)cyclohex-1-en-1-yl)acrylic acid 

Downstream Products

• 1145719-95-4 C₅H₁₀O*C₂₉H₃₄N₂O₅ 
• 900161-13-9 ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-hydroxyformyl-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamic acid ethyl ester 

Relevant academic research and scientific papers

Preparation method of vorapaxar intermediate

The invention belongs to the field of organic synthesis and drug synthesis, and relates to a preparation method of a vorapaxar intermediate. The preparation method comprises following steps: racemic (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid or an ester compound of (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid is reacted with D-malic acid so as to obtain optically pure (R, E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid or a D-malate of the ester compound of (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid via resolution, and the obtained product is converted into (R,E)-3-(5-((ethoxycarbonyl)amino) cyclohexyl-1-ene-1-yl) acrylic acid; and at last the intermediate is converted into a subsequent intermediate of vorapaxar. Compared with the prior art, the preparation method possessesfollowing advantages: the yield is increased obviously, the raw materials are easily available; the production cost is low; the preparation method is simple; operation is convenient; the reaction reagents are friendly to the environment; the preparation method is better than the prior art, and is especially suitable for industrialized production.

Vorapaxar intermediate and preparation method thereof

The invention discloses a vorapaxar intermediate and a preparation method thereof. The invention provides the preparation method of the vorapaxar intermediate I, wherein the preparation method comprises the following steps: in a closed system, and under c

HIGH PURITY SYNTHETIC PROCESS FOR THE PREPARATION OF DODECAHYDRO-NAPTHO-FURANYL-CARBAMIC ACID ESTER INTERMEDIATES

This application discloses a novel process to synthesize himbacine analog compounds, and intermediates of formula (I) useful in the synthesis thereof. The subject compounds are useful as Thrombin Receptor Antagonists with useful pharmaceutical properties.

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught her