900161-12-8

Basic information

• Product Name: Vorapaxar
• Synonyms: [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(Diphenylamino)carbonyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]carbamic acid ethyl ester;ethyl((1R,3aR,4aR,6R,8aR,9S,9aS)-9-(diphenylcarbamoyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate;ethyl(1R,3aR,4aR,6R,8aS,9S,9aS)-9-(diphenylcarbamoyl)-1,4a-dimethyl-3-oxododecahydroaphtho[2,3-c]furan-6-ylcarbamate;Ethyl [(1R,3aR,4aR,6R,8aR,9aS)-9-(diphenylcarbamoyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
• CAS NO: 900161-12-8
• Molecular Formula: C₂₉H₃₄N₂O₅
• Molecular Weight: 490.59
• Mol File: 900161-12-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 733.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 12.42±0.60(Predicted)
• CAS DataBase Reference: Vorapaxar(CAS DataBase Reference)
• NIST Chemistry Reference: Vorapaxar(900161-12-8)
• EPA Substance Registry System: Vorapaxar(900161-12-8)

Safety Data

• Hazardous Substances Data: 900161-12-8(Hazardous Substances Data)

Usage

Uses

[(1R,?3aR,?4aR,?6R,?8aR,?9S,?9aS)?-?9-?[(Diphenylamino)?carbonyl]?dodecahydro-?1-?methyl-?3-?oxonaphtho[2,?3-?c]?furan-?6-?yl]?-?carbamic Acid Ethyl Ester is a related compound of Himbacine (H456343), an alkaloid muscarinic receptor antagonist.

Upstream product

• 899809-64-4 3-(5-nitro-cyclohex-1-enyl)-acrylic acid 
• 899809-61-1 (R,Z)-4-hydroxy-N,N-diphenylpent-2-ynamide 
• 900161-09-3 (R,E)-3-(5-((ethoxycarbonyl)amino)cyclohex-1-en-1-yl)acrylic acid 
• 900161-11-7 C₂₉H₃₂N₂O₅ 
• 900161-09-3 C₁₂H₁₇NO₄ 
• 900186-76-7 C₂₆H₃₀N₂O₃ 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1145719-95-4 C₅H₁₀O*C₂₉H₃₄N₂O₅ 
• 900161-13-9 ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-hydroxyformyl-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamic acid ethyl ester 

Relevant articles and documents

Preparation method of vorapaxar intermediate

The invention belongs to the field of organic synthesis and drug synthesis, and relates to a preparation method of a vorapaxar intermediate. The preparation method comprises following steps: racemic (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid or an ester compound of (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid is reacted with D-malic acid so as to obtain optically pure (R, E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid or a D-malate of the ester compound of (E)-3-(5-amino cyclohexyl-1-ene-yl) acrylic acid via resolution, and the obtained product is converted into (R,E)-3-(5-((ethoxycarbonyl)amino) cyclohexyl-1-ene-1-yl) acrylic acid; and at last the intermediate is converted into a subsequent intermediate of vorapaxar. Compared with the prior art, the preparation method possessesfollowing advantages: the yield is increased obviously, the raw materials are easily available; the production cost is low; the preparation method is simple; operation is convenient; the reaction reagents are friendly to the environment; the preparation method is better than the prior art, and is especially suitable for industrialized production.

HIGH PURITY SYNTHETIC PROCESS FOR THE PREPARATION OF DODECAHYDRO-NAPTHO-FURANYL-CARBAMIC ACID ESTER INTERMEDIATES

This application discloses a novel process to synthesize himbacine analog compounds, and intermediates of formula (I) useful in the synthesis thereof. The subject compounds are useful as Thrombin Receptor Antagonists with useful pharmaceutical properties.