900174-64-3 Usage
Uses
Used in Pharmaceutical Industry:
4-Bromo-2-ethoxy-1-fluorobenzene is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique combination of functional groups allows for the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-2-ethoxy-1-fluorobenzene is utilized as a starting material for the production of agrochemicals. Its chemical structure can be manipulated to develop compounds that can be used in crop protection and pest control.
Used in Organic Material Production:
4-Bromo-2-ethoxy-1-fluorobenzene is employed in the production of organic materials, where its functional groups contribute to the formation of new materials with specific properties, such as improved stability or reactivity.
Used in Fine Chemicals Manufacturing:
As an intermediate in the manufacturing of other fine chemicals, 4-Bromo-2-ethoxy-1-fluorobenzene plays a crucial role in the synthesis of specialty chemicals used in various industries, including fragrances, dyes, and coatings. Its versatility in organic chemistry reactions makes it a valuable component in the development of these精细化工产品 (which translates to "fine chemicals" in English).
Check Digit Verification of cas no
The CAS Registry Mumber 900174-64-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,1,7 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 900174-64:
(8*9)+(7*0)+(6*0)+(5*1)+(4*7)+(3*4)+(2*6)+(1*4)=133
133 % 10 = 3
So 900174-64-3 is a valid CAS Registry Number.
900174-64-3Relevant academic research and scientific papers
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC
Kline, Toni,Andersen, Niels H.,Harwood, Eric A.,Bowman, Jason,Malanda, Andre,Endsley, Stephanie,Erwin, Alice L.,Doyle, Michael,Fong, Susan,Harris, Alex L.,Mendelsohn, Brian,Mdluli, Khisimuzi,Raetz, Christian R. H.,Stover, C. Kendall,Witte, Pamela R.,Yabannavar, Asha,Zhu, Shuguang
, p. 3112 - 3129 (2007/10/03)
Deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine by LpxC is the first committed step in the Pseudomonas aeruginosa biosynthetic pathway to lipid A; homologous enzymes are found widely among Gram-negative bacteria. As an essential enzyme for which no inhibitors have yet been reported, the P. aeruginosa LpxC represents a highly attractive target for a novel antibacterial drug. We synthesized several focused small-molecule libraries, each composed of a variable aromatic ring, one of four heterocyclic/spacer moieties, and a hydroxamic acid and evaluated the LpxC inhibition of these compounds against purified P. aeruginosa enzyme. To ensure that the in vitro assay would be as physiologically relevant as possible, we synthesized a tritiated form of the specific P. aeruginosa glycolipid substrate and measured directly the enzymatically released acetate. Several of our novel compounds, predominantly those having fluorinated substituents on the aromatic ring and an oxazoline as the heterocyclic moiety, demonstrated in vitro IC50 values less than 1 μM. We now report the synthesis and in vitro evaluation of these P. aeruginosa LpxC inhibitors.
