900174-65-4Relevant articles and documents
BENZAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
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Page/Page column 29, (2010/09/17)
The present invention provides novel benzamide derivatives of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, W, Y, Z, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
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Page/Page column 99-100, (2008/06/13)
The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.