9002-12-4

Basic information

• Product Name: URICASE
• Synonyms: EC 1.7.3.3;EC: 1.7.3.3;IUB: 1.7.3.3;URATE: O2 OXIDOREDUCTASE;URATE OXIDASE;URATE: OXIDOREDUCTASE;URATE: OXYGEN OXIDOREDUCTASE;URATE: OXYGEN OXOREDUCTASE
• CAS NO: 9002-12-4
• Molecular Formula: C18H26N5O14P
• Molecular Weight: 567.397901
• EINECS: 232-655-5
• Product Categories: 1.7.x.x Other nitrogenous donors;1.x.x.x Oxidoreductases;General Metabolic Enzymes;General Metabolic Enzymes I-ZEnzyme Class Index;Metabolomics;enzyme
• Mol File: 9002-12-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Water Solubility: Hardly soluble in water, slightly soluble in buffer alkaline solution.
• Merck: 13,9944
• CAS DataBase Reference: URICASE(CAS DataBase Reference)
• NIST Chemistry Reference: URICASE(9002-12-4)
• EPA Substance Registry System: URICASE(9002-12-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YU7100000
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 9002-12-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 9002-12-4 differently. You can refer to the following data:
1. In the determination of serum and urine uric acid.
2. Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.
3. Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.

General Description

Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.

Biochem/physiol Actions

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .