9002-17-9 Usage
Description
An enzyme that is closely
related to aldehyde oxidase (EC 1.2.3.1). Both are metalloflavoproteins of about 300,000 daltons. They consist of two subunits of equal size and contain molybdenum, FAD, and iron
(as Fe/S) in a ratio of 1:1:4 per subunit. These enzymes are
widely distributed and catalyze a reaction in which the substrate is hydroxylated by an oxygen atom derived from water
and electrons from the substrate are transferred to a variety of
acceptors. These two enzymes have a broad overlapping substrate specificity including many purines, pyrimidines, and
pteridines. However, xanthine, the best known substrate for
xanthine oxidase, is not a substrate for aldehyde oxidase
whereas the reverse is true for quaternary pyridinium compounds, such as N0
-methylnicotinamide. The role of oxygen as
an electron acceptor with its production of hydrogen peroxide
and the intermediate superoxide anion (both potential toxicants) may not be important in vivo since there is evidence
that these enzymes are NAD-dependent dehydrogenases
in vivo and become oxidases as a result of modification during
purification. However, they are probably important in two
types of detoxication. The first of these is the hydroxylation of
exogenous aldehydes, purines, pyrimidines and other heterocyclic compounds, and the second involves the utilization of
exogenous compounds as electron acceptors. Examples of the
latter include the conversion of organic nitro compounds to
hydroxyamino derivatives and the reduction of N-oxides to the
free base.
Chemical Properties
Light brown powder
Uses
Different sources of media describe the Uses of 9002-17-9 differently. You can refer to the following data:
1. Xanthine Oxidase from bovine milk has been used:in the preparation of xanthine oxidase (XO) solution for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO)-spin trapping assayin in?vitro XO assay for screening Vietnamese medicinal plants for XO inhibitory activityas a standard to determine XO activityas a standard to test the synergistic effect of docosahexaenoic acid (DHA)
2. This enzyme is useful for enzymatic determination of inorganic phosphorus, 5′-nucleotidase and adenosine deaminase when coupled with Purine-nucleoside phosphorylase (PNP-301) and uricase (UAO-201, UAO-211).
Definition
An enzyme found in animal
tissues that acts upon hypoxanthine, xanthine, aldehydes,
reduced coenzyme I, etc., producing, respectively,
xanthine, uric acid, acids, oxidized coenzyme
I, etc.
General Description
Formerly E.C. 1.1.3.22
Biochem/physiol Actions
Hydroxylation of hypoxanthine to xanthine and xanthine to uric acid is catalyzed by xanthinebb oxidase (XO) enzyme.
Check Digit Verification of cas no
The CAS Registry Mumber 9002-17-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 9002-17:
(6*9)+(5*0)+(4*0)+(3*2)+(2*1)+(1*7)=69
69 % 10 = 9
So 9002-17-9 is a valid CAS Registry Number.
