90037-20-0

Basic information

• Product Name: 1-Propyl-3-hydroxypyridine-2(1H)-one
• Synonyms: 1-Propyl-3-hydroxypyridine-2(1H)-one;3-Hydroxy-1-propylpyridin-2(1H)-one
• CAS NO: 90037-20-0
• Molecular Formula: C8H11NO2
• Molecular Weight: 0
• Mol File: 90037-20-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propyl-3-hydroxypyridine-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propyl-3-hydroxypyridine-2(1H)-one(90037-20-0)
• EPA Substance Registry System: 1-Propyl-3-hydroxypyridine-2(1H)-one(90037-20-0)

Safety Data

• Hazardous Substances Data: 90037-20-0(Hazardous Substances Data)

Upstream product

• 20928-63-6 3-methoxy-1H-pyridin-2-one 
• 107-08-4 1-iodo-propane 
• 84719-32-4 3-Hydroxy-2(1H)-pyridinone 

Relevant articles and documents

Synthesis of oxovanadium complexes and their apoptosis-inducing activity in leukemia cells

Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes - 3b and 4 - exhibited strong activities with IC50 values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells.

Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties, and biological activity

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2(1H)-pyridinone is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes have been determined. The stability constant of the iron(III) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron(III) complexes were also determined. One of the novel hexadentate compounds has been shown to markedly enhance iron(III) excretion from both hepatocytes and iron-overloaded mice.