84719-32-4

Basic information

• Product Name: 2,3-DIHYDROXYPYRIDINE
• Synonyms: TIMTEC-BB SBB004333;PYRIDINE-2,3-DIOL
• CAS NO: 84719-32-4
• Molecular Formula: C₅H₅NO₂
• Molecular Weight: 111.1
• EINECS: 240-887-3
• Product Categories: Pyridine;Pyridines
• Mol File: 84719-32-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 245 °C (dec.)(lit.)
• Boiling Point: 387.2 °C at 760 mmHg
• Flash Point: 188 °C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 1.35E-07mmHg at 25°C
• Refractive Index: 1.593
• PKA: 8.60±0.10(Predicted)
• CAS DataBase Reference: 2,3-DIHYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDROXYPYRIDINE(84719-32-4)
• EPA Substance Registry System: 2,3-DIHYDROXYPYRIDINE(84719-32-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UV1146700
• Hazardous Substances Data: 84719-32-4(Hazardous Substances Data)

Usage

General Description

2,3-Dihydroxypyridine (2,3-DHP) is an organic compound and a derivative of Pyridine with the formula C5H5NO2. It includes two adjacent hydroxyl groups in its structure. This chemical primarily acts as an important intermediate in the process of organic synthesis and in the manufacture of various other chemicals. Notably, it is also used in the formation of drug molecules in the pharmaceutical industry. As with all chemicals, its use and handling should be performed with care.

InChI:InChI=1/C5H5NO2/c7-4-2-1-3-6-5(4)8/h1-3,7H,(H,6,8)

Upstream product

• 504-29-0 2-aminopyridine 
• 4394-75-6 6-(chloromethyl)-4-methyl-2H-pyran-2-one 
• 159949-96-9 3-picryloxy-2(1H)-pyridone 
• 142-08-5 2-Pyridone 

Downstream Products

• 90037-21-1 3-hydroxy-1-(1'-methylethyl)pyrid-2-one 
• 90037-19-7 1-ethyl-3-hydroxy-2(1H)-pyridinone 
• 90037-20-0 3-hydroxy-1-propylpyrid-2-one 
• 129421-32-5 2,3-dihydro-1,4-dioxino<2,3-b>pyridine 
• 19365-01-6 1-methyl-3-hydroxy-2(1H)-pyridinone 
• 20928-63-6 3-methoxy-1H-pyridin-2-one 
• 23003-22-7 3-hydroxypyridine-2-thione 
• 1360152-95-9 4-morpholinomethyl-5,6-di(p-chloroanilino)-2,3-pyridinedione 
• 1360152-96-0 4-morpholinomethyl-5,6-dianilino-2,3-pyridinedione 
• 1360152-90-4 4-piperidinomethyl-5,6-di(p-chloroanilino)-2,3-pyridinedione 
• 146527-57-3 Pd(P(C₆H₅)3)2(C₅H₄NO₂)⁽¹⁺⁾*B(C₆H₅)4^(1-)={Pd(P(C₆H₅)3)2(C₅H₄NO₂)}B(C₆H₅)4 
• 146489-24-9 ReO(P(C₆H₅)3)(C₅H₂NO₂(CH₃)2)2⁽¹⁺⁾*I^(1-)={ReO(P(C₆H₅)3)(C₅H₂NO₂(CH₃)2)2}I 
• 146527-58-4 ReO(P(C₆H₅)3)(C₅H₄NO₂)2⁽¹⁺⁾*I^(1-)={ReO(P(C₆H₅)3)(C₅H₄NO₂)2}I 
• 159949-96-9 3-picryloxy-2(1H)-pyridone 

Relevant articles and documents

Improved syntheses of 5-hydroxy-2-pyridones (2,5-dihydroxypyridines)

Improved syntheses of 5-hydroxy-2-pyridone, 6-chloro-5-hydroxy-2-pyridone, 2,4-dihydroxynicotinic acid, and three methyl-substituted 5-hydroxy-2-pyridones are reported. Copyright Taylor & Francis Group, LLC.

1-hydroxy-2-pyridones, a process for their preparation, and medicaments which contain them, and intermediates formed in the preparation of the 1-hydroxy-2-pyridones

New 1-hydroxy-2-pyridones of the general formula I STR1 in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, --CR2 -- (R=H or C1 -C4 -alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1 -C4 -alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1 -C4 -alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V STR2 in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

Process for the manufacture of 1-hydroxy-2-pyridones

New 1-hydroxy-2-pyridones of the general formula SPC1 In which R1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or α-furyl, all of which may be substituted by halogen, and R2 to R4 are hydrogen or lower alkyl, or two adjacent substituents together form a trimethylene or tetramethylene chain, and in which R1 to R4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated δ-keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization.